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Angiopep-2

National Institutes of Health

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Peptides

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2016
2016
Abstract 1314: Evaluating payload delivery to the CNS from surface-modified nanoparticles
The blood-brain barrier (BBB) remains a major obstacle to treatment of intracranial tumors. Most drugs are poorly bioavailable in… 
2015
2015
Abstract 2465: Targeting HER2-positive brain metastases by incorporating the brain-penetrant Angiopep-2 peptide to an anti-HER2 antibody and anti-HER2 antibody drug conjugate
Monoclonal antibodies directed against receptor tyrosine kinases such as HER2 have been demonstrated to reduce tumor size and… 
2015
2015
P-126 Anti-CD 133 Ab / angiopep-2-conjugated immunoliposomes for targeting glioblastoma stem cells
Glioblostoma (GBM) cancer stem cells (CSCs) are considered to associating with glioblastoma cancer initiation, drug (or radio… 
2014
2014
Abstract 2657: Utilization of the Angiopep platform to enable brain penetration of therapeutic mAbs or Antibody-Drug Conjugates for treatment of brain tumors
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Monoclonal antibodies directed against receptor tyrosine… 
2014
2014
Angiopep-2-Mediated Delivery of Human Manganese Superoxide Dismutase in Brain Endothelial Cells and its Protective Effect Against Oxidative Stress
Oxidative stress has been considered as the leading cause of blood–brain barrier disruption which implicates many neurological… 
2014
2014
Angiopep-2-conjugated liposomes encapsulating γ-secretase inhibitor for targeting glioblastoma stem cells
CD133+ cell subpopulation in U87 MG cells displays glioblastoma stem cell (GSC) like properties. Notch, a key regulator of stem… 
2013
2013
Abstract P6-11-05: ANG4043, a brain-penetrant anti-HER2 mAb increases survival in mice bearing intracranial BT-474 breast tumor cells
Background: Treatment options for metastatic brain tumors originating from HER2-positive breast disease are limited due to the… 
2013
2013
Abstract 864: ANG4043: A new brain-penetrant peptide-antibody conjugate that reduces tumor growth in a HER2-positive orthotopic tumor model.
While monoclonal antibodies to receptor tyrosine kinases such as HER2 have been demonstrated to reduce tumor size and increase… 
2010
2010
Abstract 3578: New Angiochem-modified doxorubicin with increased brain penetration and efficacy against brain tumors
The blood-brain barrier (BBB) is mainly formed by brain capillary endothelial cells which are closely sealed by tight junctions… 
2010
2010
Abstract 4417: Uptake of the new paclitaxel-derivative (ANG1005) by the low-density lipoprotein receptor-related protein1 (LRP1) is related to the aggressive phenotype of glioblastoma cells
The most common primary brain tumour is glioblastoma multiforme (GBM). Despite latest cancer researches to improve the outcome of… 
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