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Matrix metalloproteinase inhibition by green tea catechins.
We have investigated the effects of different biologically active components from natural products, including green tea polyphenols (GTP), resveratrol, genistein and organosulfur compounds fromExpand
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Involvement of the low‐density lipoprotein receptor‐related protein in the transcytosis of the brain delivery vector Angiopep‐2
The blood–brain barrier (BBB) restricts the entry of proteins as well as potential drugs to cerebral tissues. We previously reported that a family of Kunitz domain‐derived peptides called AngiopepsExpand
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Identification and Design of Peptides as a New Drug Delivery System for the Brain
By controlling access to the brain, the blood-brain barrier (BBB) restricts the entry of proteins and potential drugs to cerebral tissues. We demonstrate here the transcytosis ability of aprotininExpand
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Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.
Many beneficial proprieties have been associated with polyphenols from green tea, such as chemopreventive, anticarcinogenic, antiatherogenic and antioxidant actions. In this study, we investigatedExpand
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Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep‐2
Paclitaxel is highly efficacious in the treatment of breast, head and neck, non‐small cell lung cancers and ovarian carcinoma. For malignant gliomas, paclitaxel is prevented from reaching its targetExpand
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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain.
Luminal membranes of the vascular endothelium were isolated from brain, heart and lungs by modification of their density. The presence of P-glycoprotein (P-gp) was detected by Western blotting inExpand
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Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.
1. The blood-brain barrier (BBB) contributes to brain homeostastis and fulfills a protective function by controlling the access of solutes and toxic substances to the central nervous system (CNS).Expand
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P‐glycoprotein in blood–brain barrier endothelial cells: interaction and oligomerization with caveolins
P‐glycoprotein (P‐gp), an adenosine triphosphate (ATP)‐binding cassette transporter which acts as a drug efflux pump, is highly expressed at the blood–brain barrier (BBB) where it plays an importantExpand
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Modulation of p‐glycoprotein function by caveolin‐1 phosphorylation
p‐glycoprotein (p‐gp) is an ATP‐binding cassette transporter and its overexpression is responsible for the acquisition of the multidrug resistance phenotype in human tumors. p‐gp is localized at theExpand
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Expression of multidrug‐resistance P‐glycoprotein (MDR1) in human brain tumors
Multidrug resistance (MDR) is associated with the expression of P‐glycoprotein (P‐gp), an ATP‐dependent transporter which expels anti‐cancer drugs from cells. In the present study, MDR1 P‐gp wasExpand
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