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Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA.
Molecular imaging techniques revealed that the intratumoral administration of red fluorescent protein-specific siRNA in complexes with pegylated CS-PLR significantly silenced the expression of redorescent proteins in tumor tissues in vivo.
Enhancement of DC vaccine potency by activating the PI3K/AKT pathway with a small interfering RNA targeting PTEN.
The data indicate that manipulation of the PI3K/AKT pathway via siRNA system could improve the efficacy of a DC-based tumor vaccine.
In vivo antitumor effect of cromolyn in PEGylated liposomes for pancreatic cancer.
The combination of cromolyn with gemcitabine in PEGylated liposomes demonstrated the strongest cytotoxicity to BxPC-3 pancreatic cancer cells in vitro and the highest anti-tumor activity against the Bx PC-3 tumor bearing nude mice in vivo.
Rapid detection of Listeria monocytogenes by real-time PCR in processed meat and dairy products.
The results indicate that the RT-PCR detection method with the set of primers and hybridization probe designed in this study should be useful in monitoring for L. monocytogenes in processed meat and milk products.
Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice.
It is demonstrated that PSLs provide an efficient and targeted delivery of gemcitabine and may represent a useful new treatment approach for tumors which overexpress the EGFR.
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
It is shown that combined radiotherapy and beta-lap treatment can have a significant effect on human tumor xenografts, and the growth of A549 tumors induced in immunocompromised mice could be markedly suppressed by local radiation therapy when followed by beta- Lap treatment.
Liposomal drug delivery system
  • Jin-Seok Kim
  • Chemistry
    Journal of Pharmaceutical Investigation
  • 20 May 2016
Lipid-based self-assembling vesicles were first described in 1961 and reported in 1964 by Dr. Alec D. Bangham (Bangham and Horne in J Mol Biol 8:660–668, 1964) at the Babraham Institute in Cambridge,
Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
  • H. Byun, D. Suh, +7 authors Y. Oh
  • Biology, Medicine
    Biochemical and biophysical research…
  • 1 July 2005
Results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
pH-Responsive PEG-Poly(β-amino ester) Block Copolymer Micelles with a Sharp Transition
Summary: A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and
Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates.
RAP-PDL conjugates have the potential to be used as a new nonviral gene delivery vector and cellular uptake of the transfection complexes into HepG2 cells was shown to be highly efficient and more specific to PDL-conjugated RAP compared with PLL- Conjugated one.