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Angiogenic Switch

Loss of the balance between stimulation and inhibition of new blood vessel growth. A required early step in cancer growth and metastasis.
National Institutes of Health

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Related topics

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Tumor Angiogenesis

Papers overview

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Highly Cited
2013
Highly Cited
2013
A new chromogranin A-dependent angiogenic switch activated by thrombin.
Angiogenesis, the formation of blood vessels from pre-existing vasculature, is regulated by a complex interplay of anti and… 
Highly Cited
2011
Highly Cited
2011
Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma
BackgroundVascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix… 
Highly Cited
2011
Highly Cited
2011
Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer
Prostate cancer (PCa) is the second leading cause of cancer-associated death in men. Once a tumor is established it may attain… 
Highly Cited
2008
Highly Cited
2008
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation.
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment… 
Highly Cited
2007
Highly Cited
2007
A glycolytic mechanism regulating an angiogenic switch in prostate cancer.
The generation of an "angiogenic switch" is essential for tumor growth, yet its regulation is poorly understood. In this… 
Highly Cited
2006
Highly Cited
2006
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Although induction of blood vessel growth is acknowledged as a pivotal requirement for the evolution of macroscopic tumors, the… 
Highly Cited
2004
Highly Cited
2004
Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression.
Overexpression of human cyclooxygenase 2 (COX-2) in the mammary glands of transgenic mice induces tissue-specific tumorigenic… 
Review
2004
Review
2004
Angiopoietins in tumours: the angiogenic switch
On first view, the literature pertaining to the expression of the angiopoietins in tumours is confusing and does not readily… 
Review
2003
Review
2003
Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways.
Highly Cited
2003
Highly Cited
2003
The angiogenic switch for vascular endothelial growth factor (VEGF)‐A, VEGF‐B, VEGF‐C, and VEGF‐D in the adenoma–carcinoma sequence during colorectal cancer progression
Angiogenesis is essential for tumour growth and metastasis. It is controlled by angiogenic factors, one of the most important… 
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