Angiogenic Switch

Loss of the balance between stimulation and inhibition of new blood vessel growth. A required early step in cancer growth and metastasis.
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Coined in the late eighties, the term "angiogenic switch" refers to a time-restricted event during tumor progression where the… (More)
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Highly Cited
2008
Highly Cited
2008
Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients… (More)
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Highly Cited
2007
Highly Cited
2007
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that… (More)
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Highly Cited
2007
Highly Cited
2007
A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression… (More)
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Highly Cited
2006
Highly Cited
2006
The development of a tumor vasculature or access to the host vasculature is a crucial step for the survival and metastasis of… (More)
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Highly Cited
2006
Highly Cited
2006
Matrix metalloprotease type 9 (MMP-9) has been functionally implicated in VEGF activation, the induction and maintenance of… (More)
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Review
2004
Review
2004
On first view, the literature pertaining to the expression of the angiopoietins in tumours is confusing and does not readily… (More)
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Review
2003
Review
2003
It has become evident that we cannot understand tumour growth without considering components of the stromal microenvironment… (More)
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Highly Cited
2002
Highly Cited
2002
The reactive oxygen-generating enzyme Nox1 transforms NIH 3T3 cells, rendering them highly tumorigenic and, as shown herein, also… (More)
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Highly Cited
2000
Highly Cited
2000
During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature… (More)
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