Alpha-Tectorin

Known as: Tectorin Alpha 
Alpha-tectorin (2155 aa, ~240 kDa) is encoded by the human TECTA gene. This protein plays a role in hearing.
National Institutes of Health

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Cell AdhesionCell MovementExtracellular MatrixExtracellular Matrix Protein Gene
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Papers overview

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2011
2011
Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).
We report on a secreted protein found in mammalian cochlear outer hair cells (OHC) that is a member of the carcinoembryonic… (More)
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2002
2002
Extracellular matrices associated with the apical surfaces of sensory epithelia in the inner ear: molecular and structural diversity.
The ultrastructure and molecular composition of the extracellular matrices that are associated with the apical surfaces of the… (More)
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2001
2001
Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss.
The genes for alpha- and beta-tectorin encode the major non-collagenous proteins of the tectorial membrane. Recently, a targeted… (More)
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Highly Cited
2000
Highly Cited
2000
A Targeted Deletion in α-Tectorin Reveals that the Tectorial Membrane Is Required for the Gain and Timing of Cochlear Feedback
alpha-tectorin is an extracellular matrix molecule of the inner ear. Mice homozygous for a targeted deletion in a-tectorin have… (More)
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Highly Cited
1999
Highly Cited
1999
An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21.
In our efforts to identify new loci responsible for non-syndromic autosomal recessive forms of deafness, DFNB loci, we have… (More)
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1999
1999
Tectorin mRNA expression is spatially and temporally restricted during mouse inner ear development.
The tectorial and otolithic membranes are extracellular matrices that cover the sensory epithelia of the inner ear. They are… (More)
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1999
1999
Chick alpha-tectorin: molecular cloning and expression during embryogenesis.
The avian and mammalian tectorial membranes both contain two non-collagenous glycoproteins, alpha and beta-tectorin. To determine… (More)
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1998
1998
Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment.
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory… (More)
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1998
1998
Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness.
alpha-Tectorin is one of the major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped… (More)
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Highly Cited
1997
Highly Cited
1997
The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system.
The cDNA and derived amino acid sequences for the two major non-collagenous proteins of the mouse tectorial membrane, alpha- and… (More)
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