Skip to search formSkip to main contentSkip to account menu

Alkaline Ceramidase 3

Known as: Alkaline CDase 3, Alkaline Dihydroceramidase SB89, Alkaline Phytoceramidase 
Alkaline ceramidase 3 (267 aa, ~32 kDa) is encoded by the human ACER3 gene. This protein is involved in the synthesis of phytosphingosine.
National Institutes of Health

Related topics

Related topics

8 relations
ACER3 geneACER3 wt AlleleEnzyme GeneHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress
Overload of palmitic acids is linked to the dysregulation of ceramide metabolism in nonalcoholic steatohepatitis (NASH), and… 
2020
2020
Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease
The imbalance in sphingolipid signaling may be critically linked to the upstream events in the neurodegenerative cascade of… 
2020
2020
Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease
The imbalance in sphingolipid signaling may be critically linked to the upstream events in the neurodegenerative cascade of… 
2018
2018
Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates
Sphingosine‐1‐phosphate (S1P) plays important roles in cardiovascular development and immunity. S1P is abundant in plasma because… 
2016
2016
Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy
Background/aims Leukodystrophies due to abnormal production of myelin cause extensive morbidity in early life; their genetic… 
2015
2015
ACER3 supports development of acute myeloid leukemia.
2015
2015
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14… 
2012
2012
575: Prenatal risk-drinking screening: T-ACER3 reduces T-ACE false positives
Highly Cited
2010
Highly Cited
2010
Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-chain Ceramides, and Its Down-regulation Inhibits Both Cell Proliferation and Apoptosis*
Ceramides with different fatty acyl chains may vary in their physiological or pathological roles; however, it remains unclear how… 
2003
2003
Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase
Ceramidases deacylate ceramides, important intermediates in the metabolic pathway of sphingolipids. In this study, we report the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)