Alendronate

Known as: 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate, (4-Amino-1-hydroxybutylidene)bisphosphonic Acid, Aminohydroxybutane Bisphosphonate 
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2018
010020019682018

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND Bisphosphonate therapy is the current standard of care for the prevention and treatment of glucocorticoid-induced… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the… (More)
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Highly Cited
2005
Highly Cited
2005
Alendronate, an inhibitor of bone resorption, is widely used in osteoporosis treatment. However, concerns have been raised about… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized… (More)
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Highly Cited
2000
Highly Cited
2000
We examined the effect of alendronate treatment for 3-4 yr on risk of new fracture among 3658 women with osteoporosis enrolled in… (More)
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Highly Cited
1998
Highly Cited
1998
CONTEXT Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Previous studies have shown that alendronate can increase bone mineral density (BMD) and prevent radiographically… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Postmenopausal osteoporosis is a serious health problem, and additional treatments are needed. METHODS We studied… (More)
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Highly Cited
1991
Highly Cited
1991
Studies of the mode of action of the bisphosphonate alendronate showed that 1 d after the injection of 0.4 mg/kg [3H]alendronate… (More)
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