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Alendronate

Known as: 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate, (4-Amino-1-hydroxybutylidene)bisphosphonic Acid, Aminohydroxybutane Bisphosphonate 
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND Bisphosphonate therapy is the current standard of care for the prevention and treatment of glucocorticoid-induced… Expand
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Highly Cited
2006
Highly Cited
2006
CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the… Expand
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Highly Cited
2005
Highly Cited
2005
Alendronate, an inhibitor of bone resorption, is widely used in osteoporosis treatment. However, concerns have been raised about… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Parathyroid hormone increases bone strength primarily by stimulating bone formation, whereas antiresorptive drugs… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Because parathyroid hormone increases both bone formation and bone resorption, it is possible that combining… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Despite its association with disability, death, and increased medical costs, osteoporosis in men has been relatively… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Previous studies have shown that alendronate can increase bone mineral density (BMD) and prevent radiographically… Expand
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Highly Cited
1991
Highly Cited
1991
Studies of the mode of action of the bisphosphonate alendronate showed that 1 d after the injection of 0.4 mg/kg [3H]alendronate… Expand
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