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Alendronate

Known as: 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate, (4-Amino-1-hydroxybutylidene)bisphosphonic Acid, Aminohydroxybutane Bisphosphonate 
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as… 
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (3)

5-FdU-alendronateAlendronate SodiumMaxmarvil
Alendronic acidAlendronic acid 35 MG Oral TabletDrug AllergyEsophageal Achalasia

Broader (3)

Bone Density Conservation AgentsDiphosphonatesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women.
Highly Cited
2003
Highly Cited
2003
Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs.
Review
2003
Review
2003
The role of bisphosphonates in diseases of childhood
Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. In recent… 
Highly Cited
2003
Highly Cited
2003
Prevalence and treatment of decreased bone density in renal transplant recipients: a randomized prospective trial of calcitriol versus alendronate
Background. Reduced bone mineral density (BMD) is common in long-term renal transplant recipients and results in a high incidence… 
Highly Cited
2002
Highly Cited
2002
Alendronate in the treatment of avascular necrosis of the hip.
Alendronate in the treatment of avascular necrosis of the hip SIR, Avascular necrosis (AVN) of the bone results from decreased… 
Highly Cited
2001
Highly Cited
2001
Alendronate for the Treatment of Osteoporosis in Men
The incidence of osteoporotic fracture in males is approximately one-third of that observed in women, but information on specific… 
Review
2000
Review
2000
Oral bisphosphonates
This study was conducted to review the efficacy and safety of oral bisphosphonates for the treatment of bone metastases in cancer… 
Highly Cited
1999
Highly Cited
1999
Monitoring Alendronate Therapy for Osteoporosis
Alendronate is an antiresorptive therapy for osteoporosis and results in a decrease in bone turnover. To choose the optimal… 
Highly Cited
1999
Highly Cited
1999
Evaluation of bone turnover and osteoclastic cytokines in early rheumatoid arthritis treated with alendronate.
OBJECTIVE Osteoporosis is a frequent complication of rheumatoid arthritis (RA). We investigated the effect of oral alendronate… 
Highly Cited
1997
Highly Cited
1997
Osteoclasts generate cross-linked collagen N-telopeptides (NTx) but not free pyridinolines when cultured on human bone.
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