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Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene: Results From a 3-year Randomized Clinical Trial
TLDR
It is indicated that raloxifene treatment over 3 years not only preserves bone mass but also lowers the risk of new vertebral fractures in postmenopausal women with osteoporosis, regardless of whether they have had fractures before starting treatment. Expand
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation
TLDR
In postmenopausal women with osteoporosis, raloxifene increases bone mineral density in the spine and femoral neck and reduces risk of vertebral fracture and was associated with a lower incidence of breast cancer. Expand
Hormone therapy to prevent disease and prolong life in postmenopausal women
TLDR
There is evidence that estrogen therapy decreases risk for coronary heart disease and for hip fracture, but long-term estrogen therapy increases risk for endometrial cancer and may be associated with a small increase in risk for breast cancer. Expand
Differential Effects of Teriparatide on BMD After Treatment With Raloxifene or Alendronate
TLDR
The effects of 18 months of treatment with teriparatide in patients previously treated with long‐term antiresorptive therapy are investigated using bone turnover markers and bone densitometry to investigate the bone marker and BMD response. Expand
The Association of Radiographically Detected Vertebral Fractures with Back Pain and Function: A Prospective Study
TLDR
This study examined the effect of incident vertebral fractures on back pain and back-related functional limitations in a large community-based sample of elderly women who underwent serial spinal radiography and annual assessments of backPain and disability over the same period. Expand
The effects of tibolone in older postmenopausal women.
TLDR
Tibolone reduced the risk of fracture and breast cancer and possibly colon cancer but increased therisk of stroke in older women with osteoporosis and the study was stopped at the recommendation of the data and safety monitoring board. Expand
Updated fracture incidence rates for the US version of FRAX®
TLDR
Revising the US-FRAX by updating current base population values for hip fracture and major osteoporotic fracture is recommended, with the impact likely to be a lowering of 10-year fracture probabilities. Expand
Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group.
TLDR
The rationale for the interventions being studied in each of the CT components and for the inclusion of the OS component is described, including a brief description of the scientific and logistic complexity of the WHI. Expand
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