Aggresome

A ubiquitin-rich cytoplasmic inclusion encased in vimentin found near the microtubule organizing center. It is formed in response to cellular… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
010203019962018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a… (More)
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Highly Cited
2009
Highly Cited
2009
In mammalian cells, abnormal proteins that escape proteasome-dependent degradation form small aggregates that can be transported… (More)
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Highly Cited
2006
Highly Cited
2006
The proteasome inhibitor bortezomib (formerly known as PS-341) recently received Food and Drug Administration approval for the… (More)
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Highly Cited
2005
Highly Cited
2005
We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in… (More)
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Highly Cited
2004
Highly Cited
2004
Lewy bodies (LBs), which are the hallmark pathologic features of Parkinson's disease and of dementia with LBs, have several… (More)
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Highly Cited
2003
Highly Cited
2003
The efficient clearance of cytotoxic misfolded protein aggregates is critical for cell survival. Misfolded protein aggregates are… (More)
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Highly Cited
2002
Highly Cited
2002
Neurodegenerative disorders such as Parkinson's disease (PD) and 'dementia with Lewy bodies' (DLB) are characterized… (More)
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Highly Cited
2001
Highly Cited
2001
The huntingtin exon 1 proteins with a polyglutamine repeat in the pathological range (51 or 83 glutamines), but not with a… (More)
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Highly Cited
1999
Highly Cited
1999
Formation of a novel structure, the aggresome, has been proposed to represent a general cellular response to the presence of… (More)
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Highly Cited
1998
Highly Cited
1998
Intracellular deposition of misfolded protein aggregates into ubiquitin-rich cytoplasmic inclusions is linked to the pathogenesis… (More)
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