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Acetylmuramyl-Alanyl-Isoglutamine

Known as: Acetylmuramyl-Alanyl-Isoglutamine [Chemical/Ingredient], Acetylmuramyl Alanyl Isoglutamine, D-alpha-Glutamine, N2-(N-(N-acetylmuramoyl)-L-alanyl)- 
Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (18)

B 30-muramyl dipeptideGM 53GMTP-N-DPGMur-NAc-L-Ala-D-isoGln

Broader (1)

Immunologic Adjuvants
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents.
A generally applicable synthetic approach to dipeptide-DOTAM conjugates has been developed which is based on the peralkylation of… 
Highly Cited
2001
Highly Cited
2001
Chirality organization of ferrocenes bearing podand dipeptide chains: synthesis and structural characterization.
A variety of ferrocenes bearing podand dipeptide chains have been synthesized to form an ordered structure in both solid and… 
Highly Cited
1994
Highly Cited
1994
Mycobacterial cell wall components induce the production of TNF-alpha, IL-1, and IL-6 by bovine monocytes and the murine macrophage cell line RAW 264.7.
Johne's disease is characterized by a chronic enteritis that results in granulomatous inflammation, cachexia, and eventual death… 
Highly Cited
1985
Highly Cited
1985
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.
Analogues of the renin octapeptide substrate were synthesized in which replacement of the scissile dipeptide with (3S,4S)-4-amino… 
Highly Cited
1985
Highly Cited
1985
Activation of alveolar macrophage tumoricidal activity and eradication of experimental metastases by freeze-dried liposomes containing a new lipophilic muramyl dipeptide derivative.
The ability of a member of a new class of lipophilic muramyl dipeptide (MDP) derivative, muramyl dipeptide-glyceryldipalmitate… 
Highly Cited
1981
Highly Cited
1981
Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice
The experimental system utilized in investigating the correlation between the chemical structures of muramyl peptides and their… 
Highly Cited
1980
Highly Cited
1980
Stimulation of thymocyte mitogenic protein secretion and of cytostatic activity of mouse peritoneal macrophages by trehalose dimycolate and muramyl‐dipeptide
Immunomodulators of bacterial origin, such as muramyl‐dipeptide (MDP) and trehalose dimycolate, are able to stimulate some… 
Highly Cited
1979
Highly Cited
1979
Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide.
The adjuvant effects of mycobacteria can be replaced by more chemically defined isolates of the cell walls including a water… 
Highly Cited
1978
Highly Cited
1978
N-(2-Oxoacyl)amino acids and nitriles as final products of dipeptide chlorination mediated by the myeloperoxidase/H2O2/Cl- system.
The chlorination of dipeptides by the myeloperoxidase/H2O2/Cl- system takes place at the N-terminal amino group, whereas no… 
Highly Cited
1978
Highly Cited
1978
Enhancement of carrier-specific helper T cell function by the synthetic adjuvant, N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP).
The adjuvant effect of a synthetic peptidoglycan, muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine, MDP), was studied… 
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