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Acetylmuramyl-Alanyl-Isoglutamine

Known as: Acetylmuramyl-Alanyl-Isoglutamine [Chemical/Ingredient], Acetylmuramyl Alanyl Isoglutamine, D-alpha-Glutamine, N2-(N-(N-acetylmuramoyl)-L-alanyl)- 
Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (18)

B 30-muramyl dipeptideGM 53GMTP-N-DPGMur-NAc-L-Ala-D-isoGln

Broader (1)

Immunologic Adjuvants
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

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Highly Cited
2001
Highly Cited
2001
Chirality organization of ferrocenes bearing podand dipeptide chains: synthesis and structural characterization.
A variety of ferrocenes bearing podand dipeptide chains have been synthesized to form an ordered structure in both solid and… 
Highly Cited
1992
Highly Cited
1992
cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator.
We have cloned the cDNA for Mo3, an activation Ag expressed by human monocytes and myelomonocytic cell lines after stimulation by… 
Highly Cited
1991
Highly Cited
1991
Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes.
Inhibition of HIV-1 protease (HIV-PR), the aspartic protease that cleaves specific amide bonds in precursor gag-pol proteins to… 
Highly Cited
1989
Highly Cited
1989
High‐resolution X‐ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the…
The conformation of the synthetic renin inhibitor CP‐69,799, bound to the active site of the fungal aspartic proteinase… 
Highly Cited
1987
Highly Cited
1987
Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity.
Highly Cited
1985
Highly Cited
1985
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.
Analogues of the renin octapeptide substrate were synthesized in which replacement of the scissile dipeptide with (3S,4S)-4-amino… 
Highly Cited
1984
Highly Cited
1984
Peptidoglycans as promoters of slow-wave sleep. II. Somnogenic and pyrogenic activities of some naturally occurring muramyl peptides; correlations with mass spectrometric structure determination.
Highly Cited
1982
Highly Cited
1982
Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide.
Various vesicle structures and lipid compositions have been studied to identify the optimal type of liposome for delivery of the… 
Highly Cited
1979
Highly Cited
1979
Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide.
The adjuvant effects of mycobacteria can be replaced by more chemically defined isolates of the cell walls including a water… 
Highly Cited
1976
Highly Cited
1976
Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds
Immunological activity of synthetic cell wall peptidoglycan subunits was examined in guinea pigs and mice. It was concluded that… 
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