FAQ

Acetylmuramyl-Alanyl-Isoglutamine

Known as: Acetylmuramyl-Alanyl-Isoglutamine [Chemical/Ingredient], Acetylmuramyl Alanyl Isoglutamine, D-alpha-Glutamine, N2-(N-(N-acetylmuramoyl)-L-alanyl)- 
Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2017
0102019642017

Related topics

Related topics

23 relations

Narrower (13)

B 30-muramyl dipeptideGM 53N-acetylmuramyl-alanylglutamine methyl esterN-acetylmuramyl-alanylglutamine-n-butyl ester
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Broader (1)

Immunologic Adjuvants
In BloodProcess of secretionadministration & dosageagonists
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Acetylmuramyl-Alanyl-Isoglutamine
agonists
Immunologic Adjuvants
chemical synthesis
Syntex adjuvant formulation
standards characteristics

Papers overview

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2013
2013
Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2.
BACKGROUND & AIMS Decreased levels or function of nucleotide-binding oligomerization domain 2 (NOD2) are associated with Crohn's… (More)
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2012
2012
Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP*
Nucleotide binding and oligomerization domain-containing protein 2 (NOD2/Card15) is an intracellular protein that is involved in… (More)
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Highly Cited
2009
Highly Cited
2009
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation… (More)
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2008
2008
TAK1 is a central mediator of NOD2 signaling in epidermal cells.
Muramyl dipeptide (MDP) is a peptidoglycan moiety derived from commensal and pathogenic bacteria, and a ligand of its… (More)
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2008
2008
Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.
The nucleotide-binding domain and leucine-rich repeat containing protein NOD2 serves as a cytoplasmic pattern recognition… (More)
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2006
2006
Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation.
The nucleotide oligomerization domain 2 (NOD2) 3020insC (NOD2fs) mutation increases susceptibility to Crohn's disease (CD), but… (More)
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Highly Cited
2005
Highly Cited
2005
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
The activation of innate immunity requires the amplification of signals induced by pattern-recognition receptors for bacterial… (More)
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2005
2005
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
6-O-acyl-muramyldipeptides (MDP) with various lengths of fatty acid chains were examined for their dendritic cell (DC) maturation… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome
Activation of caspase-1 and subsequent processing and secretion of the pro-inflammatory cytokine IL-1beta is triggered upon… (More)
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2002
2002
Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide.
Previously, we showed that live Salmonella-containing phagosomes (LSP) recruit early acting Rab5 and promote fusion with early… (More)
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