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This large scale computer‐assisted telephone survey was undertaken to explore the prevalence, severity, treatment and impact of… Expand Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and… Expand The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases… Expand Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… Expand Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly… Expand The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation… Expand 1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related… Expand The possibility that glutathione may protect against acetaminophen-induced hepatic necrosis was examined. Pretreatment of mice… Expand A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man… Expand Doses of 3H-acetaminophen (300-750 mg/kg) that cause necrosis in mice were shown to result in large amounts of radiolabeled… Expand