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Acetaminophen

Known as: N-(4-Hydroxyphenyl)acetanilide, ACMP, N-(4-Hydroxyphenyl)acetamide 
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
This large scale computer‐assisted telephone survey was undertaken to explore the prevalence, severity, treatment and impact of… Expand
Highly Cited
2005
Highly Cited
2005
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and… Expand
Review
2003
Review
2003
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases… Expand
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Highly Cited
2002
Highly Cited
2002
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… Expand
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Highly Cited
2001
Highly Cited
2001
Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly… Expand
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Highly Cited
1994
Highly Cited
1994
The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation… Expand
Highly Cited
1985
Highly Cited
1985
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related… Expand
Highly Cited
1973
Highly Cited
1973
The possibility that glutathione may protect against acetaminophen-induced hepatic necrosis was examined. Pretreatment of mice… Expand
Highly Cited
1973
Highly Cited
1973
A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man… Expand
Highly Cited
1973
Highly Cited
1973
Doses of 3H-acetaminophen (300-750 mg/kg) that cause necrosis in mice were shown to result in large amounts of radiolabeled… Expand