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Acetaminophen

Known as: N-(4-Hydroxyphenyl)acetanilide, ACMP, N-(4-Hydroxyphenyl)acetamide 
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has… 
National Institutes of Health

Related topics

Related topics

49 relations
ACETAMINOPHEN 675 mg in 675 mL ORAL LIQUID [Gesteira]AcetacoAcetaminophen / HydrocodoneAcetaminophen / dichloralphenazone / isometheptene

Narrower (16)

Acetaminophen / OxycodoneAcetaminophen / PropoxypheneAcetaminophen / phenyltoloxamineAnacin-3

Broader (1)

Antipyretics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Mechanisms of acetaminophen-induced liver necrosis.
Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can… 
Review
2008
Review
2008
OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.
Review
2006
Review
2006
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Review
2003
Review
2003
Acetaminophen-induced hepatotoxicity.
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases… 
Highly Cited
2002
Highly Cited
2002
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… 
Highly Cited
1994
Highly Cited
1994
Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers.
The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation… 
Highly Cited
1985
Highly Cited
1985
Free radicals in biology and medicine
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related… 
Highly Cited
1973
Highly Cited
1973
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
The possibility that glutathione may protect against acetaminophen-induced hepatic necrosis was examined. Pretreatment of mice… 
Highly Cited
1973
Highly Cited
1973
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man… 
Highly Cited
1973
Highly Cited
1973
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Doses of 3H-acetaminophen (300-750 mg/kg) that cause necrosis in mice were shown to result in large amounts of radiolabeled… 
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