Acetaminophen

Known as: N-(4-Hydroxyphenyl)acetanilide, ACMP, N-(4-Hydroxyphenyl)acetamide 
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has… (More)
National Institutes of Health

Papers overview

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Review
2018
Review
2018
BACKGROUND Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced… (More)
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Review
2017
Review
2017
OBJECTIVE The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board… (More)
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Review
2017
Review
2017
Importance Amid the current opioid epidemic in the United States, the enhanced recovery after surgery pathway (ERAS) has emerged… (More)
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Highly Cited
2012
Highly Cited
2012
Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a… (More)
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Highly Cited
2009
Highly Cited
2009
Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult and increases overall tissue injury… (More)
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Highly Cited
2005
Highly Cited
2005
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and… (More)
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Review
2003
Review
2003
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases… (More)
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Highly Cited
2002
Highly Cited
2002
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… (More)
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Highly Cited
2001
Highly Cited
2001
Nrf2, a member of the "cap 'n collar" group of transcription factors, is important for protecting cells against oxidative damage… (More)
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Highly Cited
2001
Highly Cited
2001
Nrf2, which belongs to the basic leucine zipper (bZip) transcription factor family, has been implicated as a key molecule… (More)
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