Skip to search formSkip to main contentSkip to account menu

Acetaminophen

Known as: N-(4-Hydroxyphenyl)acetanilide, ACMP, N-(4-Hydroxyphenyl)acetamide 
A p-aminophenol derivative with analgesic and antipyretic activities. Although the exact mechanism through which acetaminophen exert its effects has… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a centrilobular hepatic necrosis that can… 
Highly Cited
2005
Highly Cited
2005
Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and… 
Review
2003
Review
2003
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases… 
Highly Cited
2002
Highly Cited
2002
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the… 
Highly Cited
1994
Highly Cited
1994
The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation… 
Highly Cited
1985
Highly Cited
1985
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related… 
Highly Cited
1973
Highly Cited
1973
The possibility that glutathione may protect against acetaminophen-induced hepatic necrosis was examined. Pretreatment of mice… 
Highly Cited
1973
Highly Cited
1973
A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man…