Abnormal pyramidal signs

OBJECTIVE To date, 3 rare missense mutations in the SNCA (α-synuclein) gene and the more frequent duplications or triplications… (More)

BACKGROUND Although many recessive loci causing parkinsonism dystonia have been identified, these do not explain all cases of the… (More)

This study evaluated the gait and balance performance of two clinically distinct groups of recently diagnosed and minimally… (More)

Increasing evidence suggests relevant cortical gray matter pathology in patients with Multiple Sclerosis (MS), but how early this… (More)

Many older adults walk with a cautious and impaired gait of unknown origin, however, the relationship between fear of falling and… (More)

Juvenile amyotrophic lateral sclerosis (ALS4) is a rare autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS… (More)

Exonic and intronic mutations in Tau cause familial neurodegenerative syndromes characterized by frontotemporal dementia and… (More)

The presenting features and their subsequent evolution in 36 patients with pathologically proven or clinically probable… (More)

We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition… (More)

We studied 40 patients in 15 families from the Portuguese Azores Islands. Each family was affected by an autosomal dominant… (More)