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Abstract GABA (γ-amino butyric acid) is an important inhibitory neurotransmitter in the central nervous system. Attenuation of… Expand Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at… Expand AZD7325 [4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide] is a selective GABAAα2,3 receptor modulator… Expand Abstract Anxiolytic activity has been associated with GABAA α2 and α3 subunits. Several target compounds were identified and… Expand Exploring drug targets based on disease-associated molecular mechanisms during development is crucial for the generation of novel… Expand RationaleSedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABAA) receptor positive… Expand Compounds with selectivity for GABAA receptor subtypes may differ significantly from nonselective benzodiazepines in their… Expand AIMS
AZD7325 is a novel α2,3 -subtype-selective partial GABA-A-receptor modulator. This study investigated the pharmacodynamics… Expand AZD7325 is a selective gamma‐amino‐butyric acid (GABAA)α2, 3 receptor modulator. The aims of this analysis were to develop… Expand WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
• AZD7325 is an orally administered, potent, selective gamma-amino-butyric acid (GABA(A… Expand