AZD2066

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2017
01220122017

Papers overview

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2018
2018
Both preclinical and clinical studies have implicated glutamatergic system dysfunction in the pathophysiology of mood disorders… (More)
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Review
2017
Review
2017
Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD) are associated with a lag of onset that… (More)
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Review
2017
Review
2017
Current pharmacotherapies for major depressive disorder (MDD) have a distinct lag of onset that can prolong distress and… (More)
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Review
2015
Review
2015
The need for rapid acting antidepressants is widely recognised. There has been much interest in glutamate mechanisms in major… (More)
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2014
2014
The metabotropic glutamate receptor 5 (mGluR5) antagonists fenobam, MPEP (2-methyl-6-(phenylethynyl)pyridine), and MTEP (3-[(2… (More)
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2014
2014
Kågedal, M. 2014. Nonlinear Mixed Effects Methods for Improved Estimation of Receptor Occupancy in PET Studies. Digital… (More)
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2013
2013
AZD2066 is a new chemical entity pharmacologically characterized as a selective, negative allosteric modulator of the… (More)
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2013
2013
Static and dynamic (PBPK) prediction models were applied to estimate the drug–drug interaction (DDI) risk of AZD2066. The… (More)
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Review
2013
Review
2013
Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to… (More)
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2012
2012
BACKGROUND Selective metabotropic glutamate receptor 5 (mGluR5) antagonists inhibit transient lower oesophageal sphincter… (More)
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