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Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
- W. D. Jonge, E. V. D. Zanden, +8 authors G. Boeckxstaens
- Medicine, Biology
- Nature Immunology
- 1 August 2005
Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was… Expand
Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia.
- G. Boeckxstaens, V. Annese, +12 authors O. Busch
- The New England journal of medicine
- 11 May 2011
BACKGROUND Many experts consider laparoscopic Heller's myotomy (LHM) to be superior to pneumatic dilation for the treatment of achalasia, and LHM is increasingly considered to be the treatment of… Expand
Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.
BACKGROUND & AIMS We previously showed that intestinal inflammation is reduced by electrical stimulation of the efferent vagus nerve, which prevents postoperative ileus in mice. We propose that this… Expand
Mechanisms of postoperative ileus
Postoperative ileus is an iatrogenic condition that follows abdominal surgery. Three main mechanisms are involved in its causation, namely neurogenic, inflammatory and pharmacological mechanisms. In… Expand
Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter
- H. Bult, G. Boeckxstaens, P. Pelckmans, F. H. Jordaens, Y. M. Maercke, A. Herman
- Biology, Medicine
- 24 May 1990
INHIBITORY non-adrenergic non-cholinergic (NANC) nerves are thought to be important in the autonomie innervation of the gastrointestinal tract and other organ systems. The nature of their… Expand
The cellular composition of the human immune system is shaped by age and cohabitation
Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of cellular immune profiles of 670 healthy… Expand
Neuroimmune mechanisms in postoperative ileus
Postoperative ileus (POI) is a common clinical condition arising after almost every abdominal surgical procedure, leading to increased patient morbidity and prolonged hospitalisation. Recent advances… Expand
Efficacy of treatment for patients with achalasia depends on the distensibility of the esophagogastric junction.
BACKGROUND & AIMS Many patients with persistent dysphagia and regurgitation after therapy have low or no lower esophageal sphincter (LES) pressure. Distensibility of the esophagogastric junction… Expand
A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve, modulates the immune system in the spleen. Vagus nerve stimulation… Expand
Symptomatic reflux disease: the present, the past and the future
The worldwide incidence of GORD and its complications is increasing along with the exponentially increasing problem of obesity. Of particular concern is the relationship between central adiposity and… Expand