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Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
- W. Jonge, E. V. D. Zanden, +8 authors G. Boeckxstaens
- Medicine, Biology
- Nature Immunology
- 1 August 2005
In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages and it is concluded that the vagal anti-inflammatory pathway acts by α7 subunit–mediated Jak2-STAT3 activation. Expand
Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia.
- G. Boeckxstaens, V. Annese, +12 authors O. Busch
- The New England journal of medicine
- 11 May 2011
After 2 years of follow-up, laparoscopic Heller's myotomy, as compared with pneumatic dilation, was not associated with superior rates of therapeutic success. Expand
Outcomes of treatment for achalasia depend on manometric subtype.
A higher percentage of patients with type II achalasia (based on manometric tracings) are treated successfully with pneumatic dilation or laparoscopic Heller myotomy than patients with types I and III a Chalasia. Expand
Mechanisms of postoperative ileus
The mechanisms underlying the recruitment of the inflammatory cells, and their interaction with the intestinal afferent innervation, are discussed and opioids administered for postoperative pain control contribute to a large extent to the reduction in propulsive gastrointestinal motility observed after abdominal surgery. Expand
Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.
In peritoneal macrophages, both nicotinic agonists reduced nuclear factor kappaB transcriptional activity and proinflammatory cytokine production, with nicotine being more effective than AR-R17779. Expand
Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter
- H. Bult, G. Boeckxstaens, P. Pelckmans, F. Jordaens, Y. M. Maercke, A. Herman
- Biology, Medicine
- 24 May 1990
Using a superfusion bioassay, the release of a vasorelaxant factor is reported upon stimulation of the NANC nerves in the canine ileocolonic junction, indicating that NO accounted for the biological activity of this transferable NANC factor. Expand
Symptomatic reflux disease: the present, the past and the future
The view on GORD has evolved enormously compared to that of the past, and without doubt will impact on how to deal with GORD in the future. Expand
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
The results provide a framework for understanding host–macrophage interactions in both the healthy and diseased brain and identify IRF8 as a master regulator that drives the maturation and diversity of brain macrophages. Expand
Neuroimmune mechanisms in postoperative ileus
Pharmacological interventions preventing the activation of these immune cells reduce the influx of leucocytes into the intestine, an effect associated with a reduction of the duration of POI. Expand
A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
It is shown that the anti-inflammatory effect of the VNS in the intestine is independent of the spleen and T cells, and intestinal muscularis resident macrophages expressing α7nAChR are most likely the ultimate target of the gastrointestinal CAIP. Expand