AZD1656

Glucokinase activators (GKAs) are newly drug class proposed for diabetes treatment. This systematic review aimed to assess the… Expand

To study the effect of exogenous i.m. glucagon on recovery from controlled insulin‐induced hypoglycaemia in patients with type 2… Expand

Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose homeostasis primarily through its regulatory… Expand

To investigate the effect of glucokinase activator AZD1656 on glycated haemoglobin (HbA1c) as an add‐on to metformin in patients… Expand

To assess the glucose‐lowering effects of monotherapy with the glucokinase activator AZD1656 in Japanese patients with type 2… Expand

Abstract Glucokinase is an enzyme responsible for the conversion of glucose into glucose-6 phosphate and plays a central role as… Expand

Glucokinase plays a central role in glucose homeostasis and small molecule activators of the glucokinase enzyme have been the… Expand

CONTEXT Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses… Expand

OBJECTIVES AZD1656 is a novel glucokinase activator with a postulated dual mechanism of action by activating glucokinase in both… Expand

To assess the safety, pharmacokinetics and pharmacodynamics of multiple‐ascending doses of the novel glucokinase activator… Expand