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AZD1656

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
To test the hypothesis that glucokinase activators (GKAs) induce hepatic adaptations that alter intra‐hepatocyte metabolite… 
Review
2014
Review
2014
Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose homeostasis primarily through its regulatory… 
2014
2014
To study the effect of exogenous i.m. glucagon on recovery from controlled insulin‐induced hypoglycaemia in patients with type 2… 
Highly Cited
2013
Highly Cited
2013
To investigate the effect of glucokinase activator AZD1656 on glycated haemoglobin (HbA1c) as an add‐on to metformin in patients… 
2013
2013
To assess the glucose‐lowering effects of monotherapy with the glucokinase activator AZD1656 in Japanese patients with type 2… 
Review
2013
Review
2013
Abstract Glucokinase is an enzyme responsible for the conversion of glucose into glucose-6 phosphate and plays a central role as… 
2012
2012
Glucokinase plays a central role in glucose homeostasis and small molecule activators of the glucokinase enzyme have been the… 
2012
2012
CONTEXT Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses… 
2012
2012
OBJECTIVES AZD1656 is a novel glucokinase activator with a postulated dual mechanism of action by activating glucokinase in both… 
2012
2012
To assess the safety, pharmacokinetics and pharmacodynamics of multiple‐ascending doses of the novel glucokinase activator…