AZD1656
National Institutes of Health
Papers overview
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To test the hypothesis that glucokinase activators (GKAs) induce hepatic adaptations that alter intra‐hepatocyte metabolite…
Glucose-phosphorylating enzyme, glucokinase (GK) plays a major role in glucose homeostasis primarily through its regulatory…
To study the effect of exogenous i.m. glucagon on recovery from controlled insulin‐induced hypoglycaemia in patients with type 2…
To investigate the effect of glucokinase activator AZD1656 on glycated haemoglobin (HbA1c) as an add‐on to metformin in patients…
To assess the glucose‐lowering effects of monotherapy with the glucokinase activator AZD1656 in Japanese patients with type 2…
Abstract Glucokinase is an enzyme responsible for the conversion of glucose into glucose-6 phosphate and plays a central role as…
Glucokinase plays a central role in glucose homeostasis and small molecule activators of the glucokinase enzyme have been the…
CONTEXT
Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses…
OBJECTIVES
AZD1656 is a novel glucokinase activator with a postulated dual mechanism of action by activating glucokinase in both…
To assess the safety, pharmacokinetics and pharmacodynamics of multiple‐ascending doses of the novel glucokinase activator…