Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656

@inproceedings{Waring2012PropertyBO,
  title={Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656},
  author={Michael J. Waring and David Scott Clarke and Mark A Fenwick and Linda Keren. Godfrey and Sam D. Groombridge and Craig L. Johnstone and Darren Mckerrecher and Kurt G Pike and John Wall Rayner and Graeme R. Robb and I. Wilson},
  year={2012}
}
Oral Glucose Tolerance Test Oral glucose tolerance tests were done on conscious Zucker obese fa/fa rats (age 12-13 weeks or older) fed a high fat diet (45 % kcal fat) for at least two weeks prior to experimentation. The animals were fasted for 2 hours before use for experiments. A test compound or a vehicle was given orally 120 minutes before oral administration of a glucose solution at a dose of 2 g/kg body weight. Blood glucose levels were measured using a Accucheck glucometer from tail bled… CONTINUE READING