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AZ10606120

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The P2X7 receptor (P2X7R) for ATP is a therapeutic target for pathophysiological states including inflammation, pain management… Expand
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Highly Cited
2015
Highly Cited
2015
BackgroundPancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least… Expand
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Highly Cited
2015
Highly Cited
2015
Neuroblastoma (NB) is an aggressive pediatric tumor, responsible for 15% of cancer-related deaths in childhood, lacking an… Expand
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2014
2014
The blood supply to the CNS is controlled by the tone of arteries and arterioles. However, little is known about purinergic… Expand
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Highly Cited
2014
Highly Cited
2014
As adenosine 5′‐triphosphate (ATP) released from astrocytes can modulate many neural signaling systems, the triggers and pathways… Expand
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2014
2014
P2X7 is a purinergic receptor‐channel; its activation by ATP elicits a broad set of cellular actions, from apoptosis to signals… Expand
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Highly Cited
2013
Highly Cited
2013
The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia. This study aimed to… Expand
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Highly Cited
2012
Highly Cited
2012
Controlled ATP release has been demonstrated from many neuronal and non-neuronal cell types. Once released, extracellular ATP… Expand
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2012
2012
The pancreatic stellate cells (PSCs) have complex roles in pancreas, including tissue repair and fibrosis. PSCs surround ATP… Expand
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Highly Cited
2010
Highly Cited
2010
The P2X7 receptor is a trimeric channel with three binding sites for ATP, but how the occupancy of these sites affects gating is… Expand
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