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The P2X7 receptor (P2X7R) for ATP is a therapeutic target for pathophysiological states including inflammation, pain management… Expand Neuroblastoma (NB) is an aggressive pediatric tumor, responsible for 15% of cancer-related deaths in childhood, lacking an… Expand BackgroundPancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least… Expand Phosphatidylserine (PS) exposure facilitates the removal of red blood cells (RBCs) from the circulation, potentially contributing… Expand The blood supply to the CNS is controlled by the tone of arteries and arterioles. However, little is known about purinergic… Expand As adenosine 5′‐triphosphate (ATP) released from astrocytes can modulate many neural signaling systems, the triggers and pathways… Expand P2X7 is a purinergic receptor‐channel; its activation by ATP elicits a broad set of cellular actions, from apoptosis to signals… Expand The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia. This study aimed to… Expand The pancreatic stellate cells (PSCs) have complex roles in pancreas, including tissue repair and fibrosis. PSCs surround ATP… Expand The P2X7 receptor is a trimeric channel with three binding sites for ATP, but how the occupancy of these sites affects gating is… Expand