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AXIN2 protein, human

Known as: Axin-2, Axis inhibition protein 2, human, Conductin 
Axin-2 (843 aa, ~94 kDa) is encoded by the human AXIN2 gene. This protein is involved in downregulation of the Wnt signaling pathway.
National Institutes of Health

Related topics

Related topics

11 relations
AXIN2 geneAXIN2 wt AlleleArmadillo RepeatCytoplasm

Broader (1)

Axin Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
AXIN1 and AXIN2 variants in gastrointestinal cancers.
Highly Cited
2013
Highly Cited
2013
Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease
Background WNT signalling is activated during lung tissue damage and inflammation. We investigated whether lung epithelial… 
Highly Cited
2013
Highly Cited
2013
Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors.
Carcinoid tumors are rare neuroendocrine tumors (NETs) that are increasing in incidence. Mutation and altered expression of Wnt… 
Highly Cited
2012
Highly Cited
2012
Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity
Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal… 
2008
2008
Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type β-catenin nuclear accumulation in lung tumorigenesis
β-catenin accumulation is often found in lung tumors, but only a few patients have mutations in β-catenin gene. In addition… 
Highly Cited
2006
Highly Cited
2006
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.
beta-catenin is the central signalling molecule of the canonical Wnt pathway, where it activates target genes in a complex with… 
Highly Cited
2006
Highly Cited
2006
Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability
Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in… 
Highly Cited
2006
Highly Cited
2006
Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
Acute full thickness joint surface defects can undergo repair, which involves tissue patterning and endochondral bone formation… 
Highly Cited
2006
Highly Cited
2006
Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis
AbstractSelective tooth agenesis is the most common developmental abnormality of the human dentition. To date, this abnormality… 
Review
2000
Review
2000
Control of beta-catenin signaling in tumor development.
The wnt signal transduction pathway is involved in various differentiation events during embryonic development and leads to tumor… 
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