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AXIN2 gene

Known as: MGC126582, Axin 2 Gene, conductin 
This gene is involved in signal transduction and plays a role in development.
National Institutes of Health

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Related topics

6 relations
AXIN2 protein, humanBreast CarcinomaColorectal CarcinomaNeuroblastoma

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AXIN2 wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling
Significance Hair follicle stem cells (HFSCs) remain quiescent for long periods of time during the resting phase of the hair… 
Highly Cited
2012
Highly Cited
2012
Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity
Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal… 
Highly Cited
2011
Highly Cited
2011
Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes
Oligodontia is defined as the congenital lack of six or more permanent teeth, excluding third molars. Oligodontia as well as… 
Highly Cited
2011
Highly Cited
2011
AXIN2‐associated autosomal dominant ectodermal dysplasia and neoplastic syndrome
We describe a family with a novel, inherited AXIN2 mutation (c.1989G>A) segregating in an autosomal dominant pattern with… 
Highly Cited
2004
Highly Cited
2004
Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.
Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs. Aberrations of regulation of Wnt signaling… 
Highly Cited
2002
Highly Cited
2002
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
Axin, APC, and the kinase GSK3 beta are part of a destruction complex that regulates the stability of the Wnt pathway effector… 
Highly Cited
2001
Highly Cited
2001
Axin Facilitates Smad3 Activation in the Transforming Growth Factor β Signaling Pathway
ABSTRACT Axin acts as a negative regulator in Wnt signaling through interaction with various molecules involved in this pathway… 
Highly Cited
2000
Highly Cited
2000
Hot spots in β-catenin for interactions with LEF-1, conductin and APC
Interactions between β-catenin and LEF-1/TCF, APC and conductin/axin are essential for wnt-controlled stabilization of β-catenin… 
Review
1999
Review
1999
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor
Review
1999
Review
1999
Whither goest the RGS proteins?
Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine… 
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