AXIN2 gene

Known as: MGC126582, Axin 2 Gene, conductin 
This gene is involved in signal transduction and plays a role in development.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
0102019592018

Papers overview

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2012
2012
Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signaling is pathognomonic of colorectal… (More)
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2006
2006
Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant WNT pathway signaling is an early progression event in 90% of colorectal cancers. It occurs through mutations mainly of… (More)
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Highly Cited
2002
Highly Cited
2002
Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote the… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of Wnt signaling through beta-catenin/TCF complexes is a key event in the development of various tumors, in particular… (More)
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Highly Cited
2002
Highly Cited
2002
The Wnt pathway regulates cell fate, proliferation, and apoptosis, and defects in the pathway play a key role in many cancers… (More)
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Highly Cited
2002
Highly Cited
2002
Wnt signals control decisive steps in development and can induce the formation of tumors. Canonical Wnt signals control the… (More)
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Highly Cited
2000
Highly Cited
2000
DNA mismatch repair (MMR) is associated with alterations in one of several DNA MMR genes1. The downstream functional consequences… (More)
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Highly Cited
1998
Highly Cited
1998
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a… (More)
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Highly Cited
1998
Highly Cited
1998
Using a yeast two-hybrid method, we identified a novel protein which interacts with glycogen synthase kinase 3beta (GSK-3beta… (More)
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