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Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that is characterized by motor neuron loss… Expand Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset neurodegenerative disease primarily affecting motor neurons. A… Expand Local regulation of protein synthesis in neurons has emerged as a leading research focus because of its importance in synaptic… Expand ABSTRACT The microRNA miR-122 and DDX6/Rck/p54, a microRNA effector, have been implicated in hepatitis C virus (HCV) replication… Expand Tight control of translation is fundamental for eukaryotic cells, and deregulation of proteins implicated contributes to numerous… Expand Cytogenetic imbalances are increasingly being realized as causes of autism. Here, we report a de novo translocation between the… Expand We have determined the solution structure of the C-terminal quarter of human poly(A)-binding protein (hPABP). The protein… Expand Instability of CAG DNA trinucleotide repeats is the mutational mechanism for several neurodegenerative diseases resulting in the… Expand Spinocerebellar ataxia type 2 (SCA2) is caused by expansion of a polyglutamine tract in ataxin-2, a protein of unknown function… Expand The dominant cerebellar ataxias (ADCAs) represent a clinically and genetically heterogeneous group of disorders linked by… Expand