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Cisplatin is an effective breast cancer drug but resistance often develops over prolonged chemotherapy. Therefore, we performed a… Expand Copper is an essential trace element which is involved in many important cellular functions . However, excess of copper can… Expand Menkes disease (MD) is a lethal multisystemic disorder of copper metabolism. Progressive neurodegeneration and connective tissue… Expand Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological… Expand This Review summarizes recent advances in understanding copper-transporting ATPase 1 (ATP7A), and examines the neurological… Expand Distal hereditary motor neuropathies comprise a clinically and genetically heterogeneous group of disorders. We recently mapped… Expand The copper-transporting P-type ATPases (Cu-ATPases), ATP7A and ATP7B, are essential for the regulation of intracellular copper… Expand The trace metal copper is essential for a variety of biological processes, but extremely toxic when present in excessive amounts… Expand ATP7A is a P-type ATPase that transports copper from cytosol into the secretory pathway for loading onto cuproproteins or efflux… Expand Purpose: The goal of this study was to determine the effect of small changes in ATP7A expression on the pharmacodynamics of… Expand