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Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and metabolism. Its homeostasis is tightly… Expand An unconventional interaction between SPCA2, an isoform of the Golgi secretory pathway Ca2+-ATPase, and the Ca2+ influx channel… Expand Ca(2+) is an essential and ubiquitous second messenger. Changes in cytosolic Ca(2+) trigger events critical for tumorigenesis… Expand 3.4.3. Artemisinin L 4. SPCAs L 4.1. Genes Encoding SPCAs L 4.2. Structure of SPCAs M 4.2.1. Mn2+ and Ca2+ Binding M 4.2.2… Expand Sixty percent of calcium in milk is transported across the mammary cells apical membrane by the plasma membrane Ca(2+)-ATPase 2… Expand SummaryWe report a new constellation of clinical features consisting of hypermanganesaemia, liver cirrhosis, an extrapyramidal… Expand Human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2 encoded by ATP2C2 is only expressed in a limited number of tissues, unlike the… Expand Unlike lower eukaryotes, mammalian genomes have a second gene, ATP2C2, encoding a putative member of the family of secretory… Expand Accumulation of Ca2+ into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) and by secretory… Expand Principal Component Analysis (PCA) is a useful technique for reducing the dimensionality of datasets for compression or… Expand