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ATP2C2 wt Allele

Known as: Secretory Pathway Calcium ATPase 2 Gene, DKFZp686H22230, ATPase, Ca++ Transporting, Type 2C, Member 2 wt Allele 
Human ATP2C2 wild-type allele is located in the vicinity of 16q24.1 and is approximately 96 kb in length. This allele, which encodes calcium… Expand
National Institutes of Health

Related topics

Related topics

9 relations
16q24.1ATP HydrolysisCalcium BindingHomo sapiens
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Broader (1)

ATP2C2 gene

Papers overview

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Review
2013
Review
2013
Manganese and the brain.
Manganese (Mn) is an essential trace metal that is pivotal for normal cell function and metabolism. Its homeostasis is tightly… Expand
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2013
2013
SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation
An unconventional interaction between SPCA2, an isoform of the Golgi secretory pathway Ca(2+)-ATPase, and the Ca(2+) influx… Expand
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2013
2013
Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line
BackgroundEpithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of… Expand
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Highly Cited
2010
Highly Cited
2010
Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Ca(2+) is an essential and ubiquitous second messenger. Changes in cytosolic Ca(2+) trigger events critical for tumorigenesis… Expand
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2009
2009
Mammary gland involution is associated with rapid down regulation of major mammary Ca2+-ATPases.
Sixty percent of calcium in milk is transported across the mammary cells apical membrane by the plasma membrane Ca(2+)-ATPase 2… Expand
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2008
2008
Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia—A new metabolic disorder
SummaryWe report a new constellation of clinical features consisting of hypermanganesaemia, liver cirrhosis, an extrapyramidal… Expand
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2006
2006
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.
Human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2 encoded by ATP2C2 is only expressed in a limited number of tissues, unlike the… Expand
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Highly Cited
2005
Highly Cited
2005
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain.
Unlike lower eukaryotes, mammalian genomes have a second gene, ATP2C2, encoding a putative member of the family of secretory… Expand
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Highly Cited
2005
Highly Cited
2005
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.
Accumulation of Ca(2+) into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) and by… Expand
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1998
1998
A Comparative Study of Principal Component Analysis Techniques
Principal Component Analysis (PCA) is a useful technique for reducing the dimensionality of datasets for compression or… Expand
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