FAQ

ATP2C2 wt Allele

Known as: Secretory Pathway Calcium ATPase 2 Gene, DKFZp686H22230, ATPase, Ca++ Transporting, Type 2C, Member 2 wt Allele 
Human ATP2C2 wild-type allele is located in the vicinity of 16q24.1 and is approximately 96 kb in length. This allele, which encodes calcium… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
012320052017

Related topics

Related topics

9 relations
16q24.1ATP HydrolysisCalcium BindingHomo sapiens
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Broader (1)

ATP2C2 gene

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ATP2C2 wt Allele
Hydrolysis
Homo sapiens
Ligand Binding
ATP Hydrolysis
Calcium Binding

Papers overview

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2016
2016
The Ca2+/Mn2+-transporting SPCA2 pump is regulated by oxygen and cell density in colon cancer cells.
The mammalian SPCA1 and SPCA2 ATPases localize in membranes of the secretory pathway and transport ions of Ca(2+) and Mn(2+) The… (More)
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2015
2015
The effect of TGF-beta-induced epithelial-mesenchymal transition on the expression of intracellular calcium-handling proteins in T47D and MCF-7 human breast cancer cells.
The contribution of Ca(2+) in TGF-β-induced EMT is poorly understood. We aimed to confirm the effect of TGF-β on the gene… (More)
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2013
2013
SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation
An unconventional interaction between SPCA2, an isoform of the Golgi secretory pathway Ca(2+)-ATPase, and the Ca(2+) influx… (More)
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2012
2012
Structural evolution and tissue-specific expression of tetrapod-specific second isoform of secretory pathway Ca2+-ATPase.
Secretory pathway Ca-ATPases are less characterized mammalian calcium pumps than plasma membrane Ca-ATPases and sarco-endoplasmic… (More)
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Highly Cited
2010
Highly Cited
2010
Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Ca(2+) is an essential and ubiquitous second messenger. Changes in cytosolic Ca(2+) trigger events critical for tumorigenesis… (More)
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2010
2010
Signalling: The calcium connection
 
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2008
2008
Localization of plasma membrane and secretory calcium pumps in the mammary gland.
Until recently the mechanism for the enrichment of milk with calcium was thought to be almost entirely via the secretory pathway… (More)
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2006
2006
Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.
Human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2 encoded by ATP2C2 is only expressed in a limited number of tissues, unlike the… (More)
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2005
2005
A novel isoform of the secretory pathway Ca2+,Mn(2+)-ATPase, hSPCA2, has unusual properties and is expressed in the brain.
Unlike lower eukaryotes, mammalian genomes have a second gene, ATP2C2, encoding a putative member of the family of secretory… (More)
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2005
2005
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.
Accumulation of Ca(2+) into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum Ca(2+)-ATPases (SERCAs) and by… (More)
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