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OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. HereExpand
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Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin
Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and maintenance, and has been shownExpand
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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible for hereditaryExpand
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Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures.
Bi-directional calcium (Ca(2+)) signaling between mitochondria and intracellular stores (endoplasmic/sarcoplasmic reticulum) underlies important cellular functions, including oxidative ATPExpand
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PARP16/ARTD15 Is a Novel Endoplasmic-Reticulum-Associated Mono-ADP-Ribosyltransferase That Interacts with, and Modifies Karyopherin-ß1
Background Protein mono-ADP-ribosylation is a reversible post-translational modification that modulates the function of target proteins. The enzymes that catalyze this reaction in mammalian cells areExpand
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Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2
The size and integrity of the Golgi apparatus is maintained via a tightly controlled regulation of membrane traffic using a variety of different signaling and cytoskeletal proteins. We have recentlyExpand
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Characterization and temporal development of cores in a mouse model of malignant hyperthermia
Malignant hyperthermia (MH) and central core disease are related skeletal muscle diseases often linked to mutations in the type 1 ryanodine receptor (RYR1) gene, encoding for the Ca2+ release channelExpand
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Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.
We have shown previously that Rab6, a small, trans-Golgi-localized GTPase, acts upstream of the conserved oligomeric Golgi complex (COG) and ZW10/RINT1 retrograde tether complexes to maintain GolgiExpand
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Analogs of the Golgi complex in microsporidia: structure and avesicular mechanisms of function
Microsporidia are obligatory intracellular parasites, most species of which live in the host cell cytosol. They synthesize and then transport secretory proteins from the endoplasmic reticulum to theExpand
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Calcium around the Golgi apparatus: implications for intracellular membrane trafficking.
  • M. Micaroni
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 2012
As with other complex cellular functions, intracellular membrane transport involves the coordinated engagement of a series of organelles and machineries; in the last couple of decades more importanceExpand
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