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AT13148

Known as: Multi-AGC Kinase Inhibitor AT13148 
An orally available, small molecule inhibitor of AGC group kinases, with potential antineoplastic activity. AT13148 inhibits, in an ATP-competitive… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

2-HydroxyphenethylaminePyrazoles
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

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2015
2015
A first-in-human study of the dual ROCK I/II inhibitor, AT13148, in patients with advanced cancers.
2566 Background: AT13148 is a first-in-class, orally bioavailable, dual ROCK I/II inhibitor, which potently inhibits ROCK I/II (6… 
2015
2015
Investigating the genomic basis for cancer cell response to multi-AGC kinase inhibitor AT13148
The PI3K-AKT cellular growth and survival signalling pathway is commonly deregulated in a wide range of cancers. The novel… 
2014
2014
First-in-human, first-in-class phase 1 study of a novel oral multi-AGC kinase inhibitor AT13148 in patients (pts) with advanced solid tumors.
2554 Background: Aberrant signaling through the AGC kinases is implicated as a critical driver of multiple cancers. AT13148 is a… 
2012
2012
Cancer Therapy : Preclinical AT 13148 Is a Novel , Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Purpose:Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and… 
2007
2007
AT13148, an orally bioavailable AKT kinase inhibitor with potent anti-tumor activity in both in vitro and in vivo models exhibiting AKT pathway deregulation.
B251 The AKT pathway is an important mediator of tumor cell growth and survival and activation of this pathway is associated with… 
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