FAQ

ASNS gene

Known as: ASNS, asparagine synthetase (glutamine-hydrolyzing), HUMAN COMPLEMENT FOR HAMSTER TEMPERATURE-SENSITIVE MUTANT ts11 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
051019942018

Related topics

Related topics

4 relations
AsparagineAsparagine measurementAspartate-Ammonia Ligaseasparagine synthase (glutamine-hydrolyzing) activity

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ASNS gene
Asparagine
Asparagine measurement
Aspartate-Ammonia Ligase
asparagine synthase (glutamine-hydrolyzing) activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.
L-Asparaginase (L-ASP) is a key component of therapy for acute lymphoblastic leukemia. Its mechanism of action, however, is still… (More)
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Highly Cited
2010
Highly Cited
2010
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.
The transcription factor ATF4 regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER… (More)
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2008
2008
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines.
BACKGROUND Asparaginase (ASNase) is an essential component of most treatment protocols for childhood acute lymphoblastic leukemia… (More)
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Highly Cited
2007
Highly Cited
2007
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.
The integrated stress response (ISR) is defined as a highly conserved response to several stresses that converge to the induction… (More)
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Highly Cited
2007
Highly Cited
2007
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase.
Because of their low asparagine synthetase (ASNS) expression and asparagine biosynthesis, acute lymphoblastic leukemia (ALL… (More)
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2007
2007
CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations.
Mitochondrial dysfunction caused by mutations in mitochondrial DNA (mtDNA) is related to a variety of diseases including MELAS… (More)
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2005
2005
A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.
To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used cDNA microarrays to obtain a genome… (More)
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Highly Cited
2004
Highly Cited
2004
Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine…
Expression of human asparagine synthetase (ASNS), which catalyzes asparagine and glutamate biosynthesis, is transcriptionally… (More)
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2003
2003
Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by…
Transcription from the ASNS (asparagine synthetase) gene is increased in response to either amino acid (amino acid response) or… (More)
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2003
2003
Social research in an integrated science of nutrition: future directions.
This paper is one in a series from the American Society of Nutritional Sciences Long Range Planning Committee, in which we are… (More)
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