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Aspartate-Ammonia Ligase
Known as:
Aspartate-Ammonia Ligase [Chemical/Ingredient]
, Synthetase, Asparagine
, L-Aspartate:ammonia ligase (AMP-forming)
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An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.
National Institutes of Health
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Related topics
Related topics
10 relations
ASNS gene
In Blood
Process of secretion
antagonists & inhibitors
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Asparagine Synthetase B
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
The regulation of nodulation, nitrogen fixation and ammonium assimilation under a carbohydrate shortage stress in the Discaria trinervis-Frankia symbiosis
C. Valverde
,
L. Wall
Plant and Soil
2003
Corpus ID: 8183248
N2-fixation is sensitive to limitation in the availability of newly synthesised carbohydrates for the nodules. We decided to…
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1995
1995
Human monocytic leukemia expresses low levels of asparagine synthase and is potentially sensitive to L-asparaginase.
A. Codegoni
,
A. Biondi
,
V. Conter
,
G. Masera
,
A. Rambaldi
,
M. D’Incalci
Leukemia
1995
Corpus ID: 12458746
1987
1987
Sequential high-dose ara-C and asparaginase versus high-dose ara-C alone in the treatment of patients with relapsed and refractory acute leukemias.
R. Capizzi
,
B. Powell
Seminars in Oncology
1987
Corpus ID: 38434424
In consideration of the full spectrum of hematologic and nonhematologic toxicity juxtaposed to the response rates (Tables 2-5…
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Review
1981
Review
1981
Role of asparaginase synthetase and asparagyl-transfer RNA synthetase in the cell-killing activity of asparaginase in Chinese hamster ovary cell mutants.
M. Waye
,
C. Stanners
Cancer Research
1981
Corpus ID: 31265254
The cell-killing activity of asparaginase on three classes of Chinese hamster ovary cell mutants was examined: a mutant which…
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1979
1979
Cloning and expression of the Escherichia coli replication origin in a single-stranded DNA phage.
J. Kaguni
,
L. S. LaVerne
,
D. Ray
Proceedings of the National Academy of Sciences…
1979
Corpus ID: 20862567
The Escherichia coli DNA replication origin (oriC) and the adjacent asparagine synthetase gene (asnA) have been inserted into the…
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1975
1975
Glutamine-dependent asparagine synthetase in fetal, adult and neoplastic rat tissues.
Y. Z. Huang
,
E. Knox
Enzyme
1975
Corpus ID: 41366060
Three enzyme reactions related to asparagine synthesis were studied in rat tissues: formation of aspartylhydroxamate, either from…
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1974
1974
Enzymatic and nutritional evidence for two-stage exression of the asparagine synthetase locus in L5178y murine leukemia mutants.
J. Uren
,
W. P. Summers
,
R. Handschumacher
Cancer Research
1974
Corpus ID: 32654935
The initial mutation of the asparagine-dependent L5178Y murine lymphoblastic leukemia cells to asparagine independence is…
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1973
1973
Asparagine-requiring tumor cell lines and their non-requiring variants: cytogenetics, biochemistry and population dynamics.
J. Colofiore
,
J. Morrow
,
M. K. Patterson
Genetics
1973
Corpus ID: 989720
Asparagine-requiring Jensen and Walker rat tumor cells and their asparagine-independent variants have been analyzed. The…
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1970
1970
Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists.
C. Haskell
,
G. Canellos
Cancer Research
1970
Corpus ID: 9319603
Summary Resistance to l-asparagine depletion in tumor cells has been correlated with asparagine biosynthesis mediated by the…
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Highly Cited
1969
Highly Cited
1969
The asparagine synthetase of Escherichia coli. II. Studies on mechanism.
H. Cedar
,
J. H. Schwartz
Journal of Biological Chemistry
1969
Corpus ID: 43774590
Abstract Asparagine synthetase, purified 370-fold from extracts of Escherichia coli K-12, catalyzed the transfer of oxygen from…
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