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ASKP1240

National Institutes of Health

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Monoclonal Antibodies

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Modulating T Cell costimulation to prevent renal allograft rejection in nonhuman primates
Organ transplantation is often the best therapeutic approach for end-stage organ failure. Graft rejection is the major obstacle… 
2017
2017
Pharmacokinetics and Safety Profile of Bleselumab (ASKP1240) in Patients With Moderate-To-Severe Plaque Psoriasis: Results from a Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Sequential…
Highly Cited
2014
Highly Cited
2014
Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects
Blocking the CD40–CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in… 
2014
2014
Patent foramen ovale and gut ischemia in potential intestinal transplant recipients.
1. Oura T, Yamashita K, Suzuki T, et al. Longterm hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman… 
Highly Cited
2013
Highly Cited
2013
A Phase 1, Randomized Ascending Single‐Dose Study of Antagonist Anti‐Human CD40 ASKP1240 in Healthy Subjects
This first‐in‐human, phase I study evaluated the safety, tolerability, pharmacokinetic and pharmacodynamic profile of ASKP1240 in… 
Review
2013
Review
2013
Novel immunosuppressive agents in kidney transplantation.
Excellent outcomes have been achieved in the field of renal transplantation. A significant reduction in acute rejection has been… 
Review
2013
Review
2013
ASKP1240, a Fully Human Anti-CD40 Monoclonal Antibody, Prolongs Pancreatic Islet Allograft Survival in Nonhuman Primates [an abstract of dissertation and a summary of dissertation review]
Title ASKP1240, a Fully Human Anti-CD40 Monoclonal Antibody, Prolongs Pancreatic Islet Allograft Survival in Nonhuman Primates… 
2013
2013
ASKP1240, a Fully Human Anti-CD40 Monoclonal Antibody, Prolongs Pancreatic Islet Allograft Survival in Nonhuman Primates [an abstract of entire text]
2012
2012
A Phase 1b, Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Single-Dose, Pharmacokinetic, Pharmacodynamic, Safety and Tolerability Study of ASKP1240 in de novo Kidney Transplantation…
2010
2010
A Fully Novel Human Anti-CD40 Monoclonal Antibody, 4D11 (ASKP1240), Renders Allo-Antigen Stimulated CD4+T Cells To Acquire Immuno-Regulatory Function
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