Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects

@inproceedings{Okimura2014CharacterizationOA,
  title={Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects},
  author={Kazumichi Okimura and Katsutoshi Maeta and Nozomi Kobayashi and Masafumi Goto and Nobuyasu Kano and Toshiki Ishihara and Tetsunori Ishikawa and Hideki Tsumura and Akihiro Ueno and Yasuhiro Miyao and Shozo Sakuma and Fumitaka Kinugasa and Nobuaki Takahashi and Tetsuya Miura},
  booktitle={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2014}
}
Blocking the CD40-CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in rodents and nonhuman primates. However, clinical trials with anti-CD154 mAbs were halted because of high incidence of thromboembolic complications. Thus, we generated and characterized a fully human anti-CD40 mAb ASKP1240, as an alternative to anti-CD154 mAb. In vitro ASKP1240 concentration-dependently inhibited human peripheral blood mononuclear cell proliferation… CONTINUE READING

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