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ARC111

Known as: ARC-111 
National Institutes of Health

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1 relation

Broader (1)

topovale

Papers overview

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2012
2012
High-Dimensional Descriptor Selection and Computational QSAR Modeling for Antitumor Activity of ARC-111 Analogues Based on Support Vector Regression (SVR)
To design ARC-111 analogues with improved efficiency, we constructed the QSAR of 22 ARC-111 analogues with RPMI8402 tumor cells… 
2012
2012
Computational QSAR models with high-dimensional descriptor selection improve antitumor activity design of ARC-111 analogues
ARC-111 has potent topoisomerase I-targeting activity and pronounced antitumor activity. To design ARC-111 analogues with… 
2010
2010
Comparative QSAR modeling of antitumor activity of ARC-111 analogues using stepwise MLR, PLS, and ANN techniques
Dibenzo [c,h]-[1,6] naphthyridin-6-one (ARC-111) and its analogues can exhibit potent topoisomerase I targeting and antitumor… 
2008
2008
Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors
Topoisomerase I (TopoI), an established anticancer target, is an enzyme producing a single-strand DNA break during transcription… 
2008
2008
Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary…
2007
2007
ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation.
ARC-111, a small-molecule topoisomerase I inhibitor, is a potent cytotoxic drug against multiple human cancer cell lines under… 
2006
2006
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
2006
2006
Characterization of ARC-111 as a TOP 1/HIF 1α inhibitor.
Proc Amer Assoc Cancer Res, Volume 47, 2006 5540 The hypoxia-inducible factor-1 (HIF-1) transcription factor is an essential… 
2005
2005
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
Highly Cited
2003
Highly Cited
2003
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6] naphthyridin-6-one (ARC-111, topovale) is a… 
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