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AR C155858

Known as: AR-C155858 
 
National Institutes of Health

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Related topics

3 relations

Broader (2)

ThiophenesUracil
analogs & derivatives

Papers overview

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2018
2018
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
AR-C155858 and AZD3965, pyrrole pyrimidine derivatives, represent potent monocarboxylate transporter 1 (MCT1) inhibitors, with… Expand
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2018
2018
In Vitro and In Vivo Efficacy of the Monocarboxylate Transporter 1 Inhibitor AR-C155858 in the Murine 4T1 Breast Cancer Tumor Model
Monocarboxylate transporter 1 (MCT1), also known as a l-lactate transporter, is a potential therapeutic target in cancer. The… Expand
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2016
2016
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells
Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore… Expand
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2015
2015
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… Expand
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2015
2015
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… Expand
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Highly Cited
2014
Highly Cited
2014
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells… Expand
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Highly Cited
2014
Highly Cited
2014
Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and… Expand
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2014
2014
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose
PurposeMonocarboxylate transporter (MCT) inhibition represents a potential treatment strategy for γ-hydroxybutyric acid (GHB… Expand
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Highly Cited
2010
Highly Cited
2010
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858… Expand
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Highly Cited
2010
Highly Cited
2010
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane… Expand
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