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AR C155858

Known as: AR-C155858 
National Institutes of Health

Related topics

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3 relations

Broader (2)

ThiophenesUracil
analogs & derivatives

Papers overview

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Review
2020
Review
2020
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
2019
2019
Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858
The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results in severe adverse effects… 
2018
2018
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Highly Cited
2016
Highly Cited
2016
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells
Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore… 
2015
2015
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… 
Highly Cited
2014
Highly Cited
2014
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells… 
2014
2014
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… 
Highly Cited
2014
Highly Cited
2014
Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and… 
Highly Cited
2010
Highly Cited
2010
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane… 
Highly Cited
2009
Highly Cited
2009
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858… 
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