FAQ

AR C155858

Known as: AR-C155858 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
012320102018

Related topics

Related topics

3 relations

Broader (2)

ThiophenesUracil
analogs & derivatives

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
AR C155858
Uracil
Thiophenes
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
This study aims to investigate the utilization of The Warburg Effect, cancer's "sweet tooth" and natural greed for glucose to… (More)
Is this relevant?
2017
2017
Na+ /K+ -ATPase coupled to endothelin receptor type B stimulates peripheral nerve regeneration via lactate signalling.
We have recently demonstrated that endothelin (ET) is functionally coupled to Nax , a Na+ concentration-sensitive Na+ channel for… (More)
Is this relevant?
2016
2016
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.
OBJECTIVES Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore… (More)
Is this relevant?
2015
2015
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2015
2015
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation
Cancer cells robustly expel lactate produced through enhanced glycolysis via monocarboxylate transporters (MCTs) and maintain… (More)
Is this relevant?
2014
2014
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and… (More)
Is this relevant?
2014
2014
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose
Monocarboxylate transporter (MCT) inhibition represents a potential treatment strategy for γ-hydroxybutyric acid (GHB) overdose… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2014
2014
Small Molecule Therapeutics AntitumorActivity of 7-AminocarboxycoumarinDerivatives , a NewClass of Potent Inhibitors of Lactate In fl ux but Not Ef fl ux
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858… (More)
Is this relevant?
2010
2010
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 5
Is this relevant?