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AR C155858

Known as: AR-C155858 
National Institutes of Health

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3 relations

Broader (2)

ThiophenesUracil
analogs & derivatives

Papers overview

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2020
2020
Targeted sensitization of tumor cells for radiation through monocarboxylate transporters 1 and 4 inhibition in vitro
Monocarboxylate transporters (MCT) 1, 2 and 4 play an important role in tumor metabolism. The amount of lactate transported by… 
Highly Cited
2019
Highly Cited
2019
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells
AR-C155858 and AZD3965, pyrrole pyrimidine derivatives, represent potent monocarboxylate transporter 1 (MCT1) inhibitors, with… 
2019
2019
Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858
The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results in severe adverse effects… 
2018
2018
In Vitro and In Vivo Efficacy of the Monocarboxylate Transporter 1 Inhibitor AR-C155858 in the Murine 4T1 Breast Cancer Tumor Model
Monocarboxylate transporter 1 (MCT1), also known as a l-lactate transporter, is a potential therapeutic target in cancer. The… 
2018
2018
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
2018
2018
Regulation of Acetate Utilization by Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).
Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal [18F… 
2015
2015
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation
Cancer cells robustly expel lactate produced through enhanced glycolysis via monocarboxylate transporters (MCTs) and maintain… 
2014
2014
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… 
2014
2014
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose
Monocarboxylate transporter (MCT) inhibition represents a potential treatment strategy for γ-hydroxybutyric acid (GHB) overdose… 
Highly Cited
2010
Highly Cited
2010
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane… 
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