Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,002,191 papers from all fields of science
Search
Sign In
Create Free Account
AR C155858
Known as:
AR-C155858
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
3 relations
Broader (2)
Thiophenes
Uracil
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Sachin Puri
,
K. Juvale
European journal of medicinal chemistry
2020
Corpus ID: 218583809
2019
2019
Treatment of γ-Hydroxybutyric Acid and γ-Butyrolactone Overdose with Two Potent Monocarboxylate Transporter 1 Inhibitors, AZD3965 and AR-C155858
Kristin E. Follman
,
M. Morris
Journal of Pharmacology and Experimental…
2019
Corpus ID: 128362569
The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results in severe adverse effects…
Expand
2018
2018
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
A. Pivovarova
,
G. MacGregor
Biomedicine & pharmacotherapy = Biomedecine…
2018
Corpus ID: 25900876
Highly Cited
2016
Highly Cited
2016
Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells
S. Kong
,
Asbjørn Nøhr-Nielsen
,
+4 authors
S. Pedersen
Pancreas
2016
Corpus ID: 35891661
Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore…
Expand
2015
2015
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
B. Nancolas
,
R. Sessions
,
A. Halestrap
Biochemical Journal
2015
Corpus ID: 15129815
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells…
Expand
Highly Cited
2014
Highly Cited
2014
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
R. Lamb
,
H. Harrison
,
J. Hulit
,
Duncan L Smith
,
M. Lisanti
,
F. Sotgia
OncoTarget
2014
Corpus ID: 13031464
Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells…
Expand
2014
2014
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity
B. Nancolas
,
R. Sessions
,
A. Halestrap
Biochemical Journal
2014
Corpus ID: 39554409
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells…
Expand
Highly Cited
2014
Highly Cited
2014
Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux
N. Draoui
,
O. Schicke
,
+4 authors
O. Feron
Molecular Cancer Therapeutics
2014
Corpus ID: 1598862
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and…
Expand
Highly Cited
2010
Highly Cited
2010
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein
M. Ovens
,
C. Manoharan
,
Marieangela C. Wilson
,
Clare M. Murray
,
A. Halestrap
Biochemical Journal
2010
Corpus ID: 18737812
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane…
Expand
Highly Cited
2009
Highly Cited
2009
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10
M. Ovens
,
A. Davies
,
Marieangela C. Wilson
,
Clare M. Murray
,
A. Halestrap
Biochemical Journal
2009
Corpus ID: 6053977
In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE