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AR C155858

Known as: AR-C155858 
 
National Institutes of Health

Papers overview

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2018
2018
AR-C155858 and AZD3965, pyrrole pyrimidine derivatives, represent potent monocarboxylate transporter 1 (MCT1) inhibitors, with… Expand
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2018
2018
Monocarboxylate transporter 1 (MCT1), also known as a l-lactate transporter, is a potential therapeutic target in cancer. The… Expand
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2016
2016
Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely needed. The aim of this work was to explore… Expand
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2015
2015
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… Expand
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2015
2015
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells… Expand
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Highly Cited
2014
Highly Cited
2014
Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells… Expand
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Highly Cited
2014
Highly Cited
2014
High lactate concentration in tumors is associated with bad prognosis. Lactate is released by glycolytic cells in tumors and… Expand
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2014
2014
PurposeMonocarboxylate transporter (MCT) inhibition represents a potential treatment strategy for γ-hydroxybutyric acid (GHB… Expand
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Highly Cited
2010
Highly Cited
2010
In the present study we characterize the properties of the potent MCT1 (monocarboxylate transporter 1) inhibitor AR-C155858… Expand
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Highly Cited
2010
Highly Cited
2010
In mammalian cells, MCTs (monocarboxylate transporters) require association with an ancillary protein to enable plasma membrane… Expand
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