• Publications
  • Influence
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid,Expand
  • 1,111
  • 87
  • PDF
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.
Because of the particular characteristics of the tumor microenvironment and tumor angiogenesis, it is possible to design drug delivery systems that specifically target anti-cancer drugs to tumors.Expand
  • 1,582
  • 52
  • PDF
Nitric oxide synthases: which, where, how, and why?
ture that clearly identifies the specific enzyme isoform. A widely accepted nomenclature (3), which will be used in these Perspective articles, identifies the three mammalian enzyme isoforms as nNOS,Expand
  • 968
  • 32
  • PDF
Nitric Oxide and Cardiac Function: Ten Years After, and Continuing
Abstract— Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The formerExpand
  • 515
  • 27
  • PDF
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.
  • O. Féron
  • Medicine
  • Radiotherapy and oncology : journal of the…
  • 1 September 2009
Tumor cells fuel their metabolism with glucose and glutamine to meet the bioenergetic and biosynthetic demands of proliferation. Hypoxia and oncogenic mutations drive glycolysis, with the pyruvate toExpand
  • 378
  • 21
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation.
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug andExpand
  • 455
  • 17
  • PDF
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
Lactate generated from pyruvate fuels production of intracellular NAD(+) as an end result of the glycolytic process in tumors. Elevated lactate concentration represents a good indicator of theExpand
  • 424
  • 15
  • PDF
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic andExpand
  • 267
  • 15
  • PDF
Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin*
The endothelial nitric-oxide synthase (eNOS) is a key determinant of vascular homeostasis. Like all known nitric-oxide synthases, eNOS enzyme activity is dependent on Ca2+-calmodulin. eNOS isExpand
  • 580
  • 14
Endothelial Nitric Oxide Synthase Targeting to Caveolae
The endothelial isoform of nitric oxide synthase (eNOS) modulates cardiac myocyte function and is expressed in the particulate subcellular fraction. We have previously shown that eNOS is targeted toExpand
  • 598
  • 13
  • PDF