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APC2 gene

Known as: APCL, APC2, Adenomatosis Polyposis Coli 2 Gene 
This gene is involved in signal transduction and cell cycle regulation.
National Institutes of Health

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APC2 wt Allele
Adenomatous Polyposis Coli Like ProteinSignal TransductionTumor Suppression

Papers overview

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2012
2012
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization
In this study, we test two current models for the function of the tumor suppressor adenomatous polyposis coli (APC). We find that… 
2011
2011
Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila
The tumor suppressor Adenomatous polyposis coli (APC) has roles in both Wnt signaling and in actin and microtubule organization… 
2009
2009
A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila
The rearrangement of cytoskeletal elements is essential for many cellular processes. The tumor suppressor Adenomatous polyposis… 
2009
2009
Membrane Bound Axin Is Sufficient for Wingless Signaling in Drosophila Embryos
The Wingless signaling pathway controls various developmental processes in both vertebrates and invertebrates. Here I probe the… 
2005
2005
Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen.
Highly Cited
2002
Highly Cited
2002
Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs.
The regulation of signal transduction plays a key role in cell fate choices, and its disregulation contributes to oncogenesis… 
Review
2001
Review
2001
Alternatively Activated Antigen-Presenting Cells: Molecular Repertoire, Immune Regulation, and Healing
The Th1/Th2 paradigm has stimulated extensive research into the mechanisms underlying T-cell polarization; alternative activation… 
2000
2000
APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.
APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the… 
2000
2000
Identification of a brain-specific APC homologue, APCL, and its interaction with β-catenin
Highly Cited
1998
Highly Cited
1998
A Role for Cyclin-Dependent Kinase(s) in the Modulation of Fast Anterograde Axonal Transport: Effects Defined by Olomoucine and the APC Tumor Suppressor Protein
Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor… 
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