APBB2 gene

Known as: FE65-LIKE 1, FE65L, Fe65-like 
 
National Institutes of Health

Papers overview

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2009
2009
Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.
The phosphorylation of Tyr-682 residue in the intracellular domain (AID) of amyloid-beta protein precursor (AbetaPP) is… Expand
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2008
2008
Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.
Fe65L1, a member of the Fe65 family, is an adaptor protein that interacts with the cytoplasmic domain of Alzheimer amyloid… Expand
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2006
2006
Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function.
Ionotropic receptors in the neuronal plasma membrane are organized in macromolecular complexes, which assure their proper… Expand
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Highly Cited
2006
Highly Cited
2006
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia… Expand
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2005
2005
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta… Expand
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2002
2002
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression.
The functions of the Alzheimer's beta-amyloid precursor protein (APP) and of its complex with the adaptor protein Fe65 are still… Expand
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2002
2002
Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.
The FE65 adaptor protein family was identified in two-hybrid screens as proteins that bind the cytoplasmic domain of the amyloid… Expand
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Highly Cited
2001
Highly Cited
2001
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.
Using a yeast two-hybrid method, we searched for amyloid precursor protein (APP)-interacting molecules by screening mouse and… Expand
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1998
1998
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
We previously demonstrated that Fe65 protein is one of the ligands of the cytoplasmic domain of beta-amyloid precursor protein… Expand
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1998
1998
Mapping of the human and murine X11-like genes (APBA2 and Apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that…
Abnormal processing of the membrane-spanning amyloid precursor protein (APP), resulting in the production of increased amounts of… Expand
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