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APBB2 gene

Known as: FE65-LIKE 1, FE65L, Fe65-like 
 
National Institutes of Health

Papers overview

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2009
2009
Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.
The phosphorylation of Tyr-682 residue in the intracellular domain (AID) of amyloid-beta protein precursor (AbetaPP) is… Expand
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Highly Cited
2006
Highly Cited
2006
Essential roles for the FE65 amyloid precursor protein‐interacting proteins in brain development
Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia… Expand
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Highly Cited
2006
Highly Cited
2006
Fe65 Interacts with P2X2 Subunits at Excitatory Synapses and Modulates Receptor Function*
Ionotropic receptors in the neuronal plasma membrane are organized in macromolecular complexes, which assure their proper… Expand
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2005
2005
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid… Expand
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2003
2003
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
Members of the FE65 family of adaptor proteins, FE65, FE65L1, and FE65L2, bind the C-terminal region of the amyloid precursor… Expand
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Highly Cited
2002
Highly Cited
2002
Fe65, a Ligand of the Alzheimer's β-Amyloid Precursor Protein, Blocks Cell Cycle Progression by Down-regulating Thymidylate Synthase Expression*
The functions of the Alzheimer's β-amyloid precursor protein (APP) and of its complex with the adaptor protein Fe65 are still… Expand
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2002
2002
Low‐density lipoprotein receptor‐related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1
The FE65 adaptor protein family was identified in two‐hybrid screens as proteins that bind the cytoplasmic domain of the amyloid… Expand
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Highly Cited
2001
Highly Cited
2001
c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK
Using a yeast two-hybrid method, we searched for amyloid precursor protein (APP)-interacting molecules by screening mouse and… Expand
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Highly Cited
1998
Highly Cited
1998
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
We previously demonstrated that Fe65 protein is one of the ligands of the cytoplasmic domain of beta-amyloid precursor protein… Expand
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Highly Cited
1996
Highly Cited
1996
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
We identified a novel human homologue of the rat FE65 gene, hFE65L, by screening the cytoplasmic domain of beta-amyloid precursor… Expand
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