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Specific receptors for luteinizing hormone-releasing hormone (LH-RH), somatostatin, bombesin, and other peptides are found on… Expand Chemotherapy is one of the main modalities in the therapy of cancer. However, an improvement in the efficacy and a reduction in… Expand Abstract Targeted chemotherapy is a modern approach aimed at increasing the efficacy of systemic chemotherapy and reducing its… Expand We determined by immunohistochemistry the presence of LHRH receptors in surgical specimens of human non-Hodgkin's lymphomas (NHL… Expand Work on cytotoxic analogs of luteinizing hormone-releasing hormone (LH-RH), somatostatin and bombesin, designed for targeting… Expand A highly potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201), was linked to [D-Lys6]luteinizing hormone-releasing… Expand In view of non-specific toxicity of most chemotherapeutic agents against normal cells, the development of targeted chemotherapy… Expand OBJECTIVE
The aim of the study was to investigate the effects of the cytotoxic analog of luteinizing hormone-releasing hormone AN… Expand Receptors for luteinizing hormone–releasing hormone (LH‐RH) are found in about 50% of human breast carcinomas. A highly potent… Expand Doxorubicin (DOX) and its daunosamine-modified derivative, 2-pyrrolino-DOX, which is 500-1000 times more active than DOX, were… Expand