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AMER1 gene

Known as: FAM123B, RP11-403E24.2, FAMILY WITH SEQUENCE SIMILARITY 123, MEMBER B 
This gene may play a role in kidney development.
National Institutes of Health

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FAM123B wt Allele
NephroblastomaProtein FAM123BSignal Transduction

Papers overview

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2017
2017
High bone mass due to novel LRP5 and AMER1 mutations.
Highly Cited
2015
Highly Cited
2015
Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer
Purpose: Somatic mutations occur at early stages of adenoma and accumulate throughout colorectal cancer progression. The aim of… 
2013
2013
β-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein*
Background: β-Arrestins are required for Wnt/β-catenin signaling, but the mechanism of their action is unclear. Results… 
Highly Cited
2012
Highly Cited
2012
Stratification of Wilms tumor by genetic and epigenetic analysis
Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest… 
2012
2012
FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility
Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics. The Microtubule… 
Highly Cited
2011
Highly Cited
2011
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.
Highly Cited
2011
Highly Cited
2011
Amer1/WTX couples Wnt‐induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
Phosphorylation of the Wnt receptor low‐density lipoprotein receptor‐related protein 6 (LRP6) by glycogen synthase kinase 3… 
2010
2010
Expression patterns of the Wtx/Amer gene family during mouse embryonic development
WTX/AMER1 is a novel negative regulator of the WNT/β‐catenin pathway with mutations detected in Wilms' tumors and an X‐linked… 
Highly Cited
2009
Highly Cited
2009
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
Abnormalities in WNT signaling are implicated in a broad range of developmental anomalies and also in tumorigenesis. Here we… 
Highly Cited
2007
Highly Cited
2007
AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane
APC is a multifunctional tumor suppressor protein that negatively controls Wnt signaling, but also regulates cell adhesion and… 
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