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ALPP gene

Known as: SEAP, ALKALINE PHOSPHATASE, PLACENTAL, ALKALINE PHOSPHATASE, SECRETED 
This gene plays a role in phosphatase activity in the placenta.
National Institutes of Health

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4 relations
ALPP protein, humanDephosphorylationHydrolysisRegan isoenzyme

Papers overview

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2011
2011
Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology
BackgroundChinese hamster ovary (CHO) cells are among the most widely used hosts for therapeutic protein production. Yet few… 
Highly Cited
2003
Highly Cited
2003
Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone.
As a part of our program aimed at exploring the biological activity of symmetrical substitution of side chains into the… 
Highly Cited
2002
Highly Cited
2002
Placental Alkaline Phosphatase Is Efficiently Targeted to Rafts in Supported Lipid Bilayers*
Evidence is growing that biological membranes contain lipid microdomains or “rafts” that may be involved in processes such as… 
Highly Cited
2000
Highly Cited
2000
Inhibition of interleukin‐6 signaling by galiellalactone
Highly Cited
1999
Highly Cited
1999
Ligand-dependent regulation of plasmid-based transgene expression in vivo.
As gene therapy advances, the ability to regulate transgene expression will become paramount for safety and efficacy. In this… 
Highly Cited
1998
Highly Cited
1998
Cycloepoxydon, 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene and 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene, new inhibitors of eukaryotic signal transduction.
In a screening for new inhibitors of NF-KB and AP-1 mediated signal transduction pathways in COS-7 cells using secreted alkaline… 
Highly Cited
1994
Highly Cited
1994
Chemiluminescent reporter gene assays: sensitive detection of the GUS and SEAP gene products.
Chemiluminescent assays are described for the secreted alkaline phosphatase (SEAP) and beta-glucuronidase (GUS) reporter gene… 
Highly Cited
1992
Highly Cited
1992
Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase.
Placental (PLAP) and germ-cell (GCAP) alkaline phosphatases are inhibited uncompetitively by L-Leu and L-Phe. Whereas L-Phe… 
Highly Cited
1992
Highly Cited
1992
Placental alkaline phosphatase has a binding site for the human immunoglobulin-G Fc portion.
Affinity chromatography of human plasma on placental-alkaline-phosphatase-Sepharose columns (placental alkaline phosphatase, PLAP… 
Highly Cited
1990
Highly Cited
1990
First‐trimester maternal serum biochemical indicators in Down syndrome
A set of 21 early maternal serum samples (19 first‐trimester and two at 14 weeks) from pregnancies resulting in a child with Down… 
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