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Inhibition of interleukin‐6 signaling by galiellalactone
A search for inhibitors of the IL‐6‐mediated signal transduction in HepG2 cells using secreted alkaline phosphatase (SEAP) as reporter gene resulted in the isolation of galiellalactone (1) from… Expand
Inhibition of NF-kappa B activation by panepoxydone.
In a search for new inhibitors of NF-kappa B mediated signal transduction in COS-7 cells using the Secreted Alkaline Phosphatase as reporter gene, panepoxydone has been isolated from fermentations of… Expand
Biochemie der Antibiotika. Struktur ‐ Biosynthese ‐ Wirkmechanismus. Von U. Gräfe. Spektrum Akademischer Verlag, Heidelberg, 1992. IX, 589 S., geb. 348.00 DM. ‐ISBN 3‐86025‐002‐7
- G. Erkel
- 1 October 1993
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells.
The fungal secondary metabolite panepoxydone has been recently described as an inhibitor of NF-kappaB activation which is a pivotal regulator of the inflammatory and immune response. These findings… Expand
Inhibitors of Inducible NO Synthase Expression: Total Synthesis of (S)‐Curvularin and Its Ring Homologues
(S)‐Curvularin and its 13‐, 14‐, and 16‐membered lactone homologues were synthesized through a uniform strategy in which a Kochi oxidative decarboxylation and ring‐closing metathesis reactions… Expand
Induction of Differentiation in Acute Promyelocytic Leukemia Cells (HL-60) by the Verticillin Derivative Sch 52900
- G. Erkel, A. Gehrt, T. Anke, O. Sterner
- Biology, Medicine
- Zeitschrift fur Naturforschung. C, Journal of…
- 1 July 2002
The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, is a widely used model system to study the cellular and molecular events involved in differentiation of leukemic cells.… Expand
Influence of apple polyphenols on inflammatory gene expression.
- M. Jung, Sven Triebel, T. Anke, E. Richling, G. Erkel
- Medicine, Biology
- Molecular nutrition & food research
- 1 October 2009
Apples (Malus spp., Rosaceae) and products thereof contain high amounts of polyphenols which show diverse biological activities and may contribute to beneficial health effects, like protecting the… Expand
Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes.
- Nadine Schmidt, A. Pautz, +5 authors H. Kleinert
- Medicine, Chemistry
- Biochemical pharmacology
- 1 March 2010
Chondrocytes are important for the development and maintenance of articular cartilage. However, both in osteoarthritis (OA) and rheumatoid arthritis (RA) chondrocytes are involved in the process of… Expand
Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol
- Annegret Serwe, Kristina Rudolph, Timm Anke, Gerhard Erkel
- Medicine, Biology
- Investigational New Drugs
- 1 June 2012
SummaryTGF-β is a multifunctional cytokine that regulates cell proliferation, differentiation, apoptosis and extracellular matrix production. Deregulation of TGF-β production or signaling has been… Expand