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AL 1576

Known as: ALO1576, AL1576, Alcon 1576 
National Institutes of Health

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Papers overview

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2012
2012
Novel Diabetic Mouse Models as Tools for Investigating Diabetic Retinopathy
Objective Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have… 
2000
2000
Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex.
2000
2000
Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.
The relative importance of sorbitol formation versus nonenzymatic glycosylation and advanced glycosylation end products (AGEs) on… 
1998
1998
Diabetic-like corneal sensitivity loss in galactose-fed rats ameliorated with aldose reductase inhibitors.
This study investigated whether diabetic-like corneal sensory deficits occur in the galactose-fed rat model of diabetic ocular… 
1998
1998
Mitochondrial aldehyde reductase: identification and characterization in rat liver and kidney cortex.
1990
1990
Chromatographic separation of activated and unactivated forms of aldose reductase.
Highly Cited
1989
Highly Cited
1989
Kinetic and structural effects of activation of bovine kidney aldose reductase.
Aldose reductase, purified to homogeneity from bovine kidney, is converted in a temperature-dependent process from a low-Km/low… 
1989
1989
DNA-synthesis regulation and correlation with inositol trisphosphate levels in cultured bovine retinal capillary pericytes.
1989
1989
Attenuation of phosphoinositidase activity and phosphatidylinositol bisphosphate level of bovine retinal capillary pericytes in high glucose.
1988
1988
AL-1576, an aldose reductase inhibitor (ARI), did not prevent the decrease of norepinephrine turnover in diabetic rats.
ONO-2235 [(E)-3-carboxymethyl-5-[(2E)-2-methyl-3-phenyl-propenylidene]rhodanine], an ARI, was reported to prevent significantly… 
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