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imirestat

Known as: 2,7-Difluorospiro(fluorene-9,4'-imidazolidine)-2',5'-dione, spiro(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

AL 1576HOE 843

Broader (2)

FluorenesHydantoins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Dose-Dependent Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat in Man
The pharmacokinetics of imirestat were studied in healthy volunteers following single and multiple oral doses. After single doses… 
1998
1998
Reduced nerve blood flow in diabetic rats: relationship to nitric oxide production and inhibition of aldose reductase
This study examined links between impaired nitric oxide production in the sciatic endoneurium, nerve blood flow, and polyol… 
Review
1994
Review
1994
Drugs designed to maintain the transparence of the ocular lens
Summary— Research into the biological basis of lens transparency has demonstrated the implication of lens sugar stress in the… 
1992
1992
Studies on the biochemical effects of the aldose reductase inhibitor 2,7-difluorospirofluorene-9,5'-imidazolidine-2',4'-dione (Al 1576, HOE 843). Detection of D-glucaric and D-glucuronic acid…
1992
1992
Application of 19F-n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor.
1. Urine from a dog dosed orally at 20 mg/kg with 14C-imirestat, a spirohydantoin aldose reductase inhibitor, contained 17.7 and… 
1991
1991
Capillary gas chromatographic-electron-capture assay for the aldose reductase inhibitor imirestat in lens and plasma.
1990
1990
Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat Following Topical Ocular Administration
The pharmacokinetics of imirestat following topical ocular administration were evaluated in a series of studies in rabbits and… 
1989
1989
Effect of protein binding on the high-performance liquid chromatography of phenytoin and imirestat in human serum by direct injection onto internal surface reversed-phase columns.
Internal surface reversed-phase (ISRP) columns have been designed to facilitate the HPLC analysis of drugs in blood serum or… 
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