AKT2 gene

Known as: PKB-BETA, PKBB, ONCOGENE AKT2 
This gene plays a role in glucose homeostasis and the inhibition of apoptosis.
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Metastasis, the cardinal feature of malignant tumors, is an important clinical variable in patient prognosis. To understand the… (More)
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Highly Cited
2006
Highly Cited
2006
Sequence mutations and gene amplifications lead to activation of the PIK3CA-AKT2 signaling pathway and have been reported in… (More)
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Highly Cited
2004
Highly Cited
2004
Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2… (More)
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Highly Cited
2003
Highly Cited
2003
To determine how AKT2 might contribute to tumor cell progression, a full-length, wild-type, human AKT2/protein kinase B (PKB)beta… (More)
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Highly Cited
2003
Highly Cited
2003
Cisplatin and its analogues have been widely used for treatment of human cancer. However, most patients eventually develop… (More)
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Highly Cited
2000
Highly Cited
2000
We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and… (More)
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Highly Cited
1998
Highly Cited
1998
AKT2, an oncogene encoding a protein serine-threonine kinase implicated in phosphatidylinositol-3-OH kinase signaling, is… (More)
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Highly Cited
1996
Highly Cited
1996
We previously demonstrated that the putative oncogene AKT2 is amplified and overexpressed in some human ovarian carcinomas. We… (More)
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Highly Cited
1995
Highly Cited
1995
The AKT2 gene is one of the human homologues of v-akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice… (More)
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Highly Cited
1992
Highly Cited
1992
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro… (More)
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