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Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China
TLDR
This is the first indication that hypnotics could be an effective ancillary treatment for COVID-19, and it is found that novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. Expand
SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls
TLDR
The SULT1A1 R213H may be a low-penetrant risk factor for developing breast cancer in Asian population and further ethnic population analysis revealed a significantly increased risk of breast cancer for HH allele carriers among Asians. Expand
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case–control studies
TLDR
A meta-analysis of 26 published studies found that COMT Val158Met polymorphism may be a low-penetrant risk factor for breast cancer development in European population. Expand
RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects
TLDR
A meta-analysis of 9 epidemiological studies involving 13,241 cases and 13,203 controls suggested the RAD51 135G>C polymorphism may contribute to breast cancer susceptibility. Expand
Low expression of WWC1, a tumor suppressor gene, is associated with aggressive breast cancer and poor survival outcome
TLDR
Low expression of WWC1 was significantly associated with advanced‐stage diseases, high‐grade tumors, and estrogen receptor‐ or progesterone receptor‐negative status and the association with relapse‐free survival remained significant after adjustment for disease stage, tumor grade, and hormone receptor status. Expand
Biological and Clinical Significance of MAD2L1 and BUB1, Genes Frequently Appearing in Expression Signatures for Breast Cancer Prognosis
TLDR
In vitro experiments demonstrated that lowering the expression of these genes by siRNAs reduced tumor cell growth and inhibited cell migration and invasion, and suggested that MAD2L1 and BUB1 may play important roles in breast cancer progression, and may assist the prediction of breast cancer prognosis. Expand
Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer.
TLDR
LncRNAs may play appreciable roles in ovarian cancer and more research is needed to elucidate their biological mechanisms and clinical implications in tumor characterization as well as disease prognosis and treatment. Expand
High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival
TLDR
High expression of lncRNA MALAT1 is associated with breast cancer relapse and may play a role in tumor progression and the association remained significant after adjustment for age at surgery, disease stage, tumor grade, and hormone receptor status. Expand
Expression and Clinical Significance of CMTM6 in Hepatocellular Carcinoma.
TLDR
The expression level and clinical significance of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) in paired hepatocellular carcinoma (HCC) and adjacent nontumor tissues are examined. Expand
ERα upregulates the expression of long non-coding RNA LINC00472 which suppresses the phosphorylation of NF-κB in breast cancer
TLDR
The study demonstrates that ERα upregulates LINC0472 which suppresses the phosphorylation of NF-κB, and suggests that endocrine treatment may lower LINC00472 and increase NF-kkB activities, leading to tumor progression and disease recurrence. Expand
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