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AKT1S1 gene

Known as: PROLINE-RICH AKT SUBSTRATE, 40-KD, AKT1S1, Lobe 
This gene plays a role in the regulation of mTOR signaling.
National Institutes of Health

Related topics

Related topics

1 relation
Signal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Trimedazidine alleviates pulmonary artery banding-induced acute right heart dysfunction and activates PRAS40 in rats
The molecular mechanism underlying acute right heart failure (RHF) is poorly understood. We used pulmonary artery banding (PAB… 
Review
2016
Review
2016
Targeting PRAS40 for multiple diseases.
2015
2015
Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
2015
2015
Inactivating frameshift mutation of AKT1S1, an mTOR inhibitory gene, in colorectal cancers
Dear Editor,Mammalian target of rapamycin (mTOR) integrates growth factor- and nutrient-linked signals and regulates cell growth… 
2014
2014
Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle
Abstract Context: Silencing proline-rich Akt substrate of 40-kDa (PRAS40) impairs insulin signalling in skeletal muscle… 
2013
2013
mTOR/PRAS40 interaction
Signals from growth factors, nutrients, energy status, as well as many stressors impinge upon the mechanistic target of rapamycin… 
2013
2013
Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells
Aims/hypothesisThe proline-rich Akt substrate of 40 kDa (PRAS40) is a component of the mammalian target of rapamycin complex 1… 
2011
2011
Calcineurin Inhibitor-Induced and Ras-Mediated Overexpression of VEGF in Renal Cancer Cells Involves mTOR through the Regulation of PRAS40
Malignancy is a major problem in patients treated with immunosuppressive agents. We have demonstrated that treatment with… 
2010
2010
BacMam-Enabled LanthaScreen® Cellular Assays for PI3K/Akt Pathway Compound Profiling in Disease-Relevant Cell Backgrounds
The authors recently reported the development and application of multiple LanthaScreen® cellular assays to interrogate specific… 
Highly Cited
2006
Highly Cited
2006
Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats
Clinical insulin resistance is associated with decreased activation of phosphatidylinositol 3′-kinase (PI3K) and its downstream… 
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