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AKT1S1 gene

Known as: PROLINE-RICH AKT SUBSTRATE, 40-KD, AKT1S1, Lobe 
This gene plays a role in the regulation of mTOR signaling.
National Institutes of Health

Related topics

Related topics

1 relation
Signal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Phosphorylation of PRAS40 in leukocytes of patients with cancer and diabetes
2017
2017
Trimedazidine alleviates pulmonary artery banding-induced acute right heart dysfunction and activates PRAS40 in rats
The molecular mechanism underlying acute right heart failure (RHF) is poorly understood. We used pulmonary artery banding (PAB… 
2016
2016
MYO 6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK 1 / 2 and PRAS 40
Prostate cancer is the second most frequently diagnosed cancer among males around the world. Myosin VI (MYO6), as a motor protein… 
2013
2013
mTOR/PRAS40 interaction
Signals from growth factors, nutrients, energy status, as well as many stressors impinge upon the mechanistic target of rapamycin… 
2013
2013
Abstract A35: Evaluation of MEK inhibitor chemosensitivity in human tumor explants using the Mosaic Blue Assay and relationship to biomarkers by immunohistochemistry.
The MEK pathway is activated in most cancers. Several chemotherapeutic agents target this pathway through inhibition of MEK, ERK… 
Review
2012
Review
2012
Role of PRAS 40 in Akt and mTOR signaling in health and disease
Wiza C, Nascimento EB, Ouwens DM. Role of PRAS40 in Akt and mTOR signaling in health and disease. Am J Physiol Endocrinol Metab… 
Review
2012
Review
2012
The challenges for drug development: cytokines, genes, and stem cells.
Abstract The development of new treatment strategies can offer exciting possibilities for individuals with neurodegenerative… 
2011
2011
Molecular Medicine in Practice PF-04691502 , a Potent and Selective Oral Inhibitor of PI 3 K and mTOR Kinases with Antitumor Activity
Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway such as by PTEN loss or PIK3CA mutation occurs frequently… 
2010
2010
Regulation of mTOR complex 1 in response to growth factors and nutrients
In multicellular organisms, cells ensure the simultaneous availability of growth factors and nutrients before they invest in… 
2007
2007
Deregulates Apoptosis in Malignant Melanoma
Malignant melanoma is the most invasive and deadly form of skin cancer with no effective therapy to treat advanced disease…