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AGS-1C4D4

Known as: AGS-1C4D4 monoclonal antibody, human, Anti-PSCA Monoclonal Antibody AGS-1C4D4, MK4721 
An IgG1k fully human monoclonal antibody directed against the human prostate stem cell antigen (PSCA) with potential antineoplastic activity. Anti… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Monoclonal Antibodies
PSCA protein, humanantigen binding

Papers overview

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2013
2013
Global , multicenter , randomized , phase II trial of gemcitabine and gemcitabine plus AGS-1 C 4 D 4 in patients with previously untreated , metastatic pancreatic cancer †
Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205–216. 11. Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment… 
2012
2012
480 Detection by Immunohistochemistry of Prostate Stem Cell Antigen (PSCA) in Tumors is Not a Predictive Biomarker for the Anti-PSCa Monoclonal Antibody AGS-1C4D4: Identification of Alternative…
2011
2011
Global, multicenter, open-label, randomized phase II trial comparing gemcitabine (G) with. G plus AGS-1C4D4 (A) in patients (pts) with metastatic pancreatic cancer (mPC).
4031 Background: A is a fully human monoclonal antibody directed against prostate stem cell antigen (PSCA), a cell surface… 
2011
2011
Abstract 4566: AGS-1C4D4: A fully human anti-PSCA antibody inhibits tumor formation and metastasis in orthotopic models of pancreatic cancer
Prostate stem cell antigen (PSCA) is a cysteine-rich cell surface glycoprotein expressed in about 50% of pancreatic and prostate… 
2011
2011
6591 POSTER Improved 6-month Survival Rate in Subjects With Prostate Stem Cell Antigen (PSCA) Positive Tumours in a Global, Randomized Phase 2 Trial Comparing Gemcitabine Vs. Gemcitabine + Ags-1c4d4…
2010
2010
Phase I dose-escalation study of AGS-1C4D4, an anti-PSCA human antibody in castration-resistant prostate cancer (CRPC).
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