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AG-1296

Known as: AG1296, tyrphostin-AG1296, AG 1296 
A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

6,7-dimethoxy-3-phenylquinoxalineNitrilesQuinoxalines
Receptor Tyrosine Kinase Inhibition

Papers overview

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Highly Cited
2007
Highly Cited
2007
TNF-α induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-κB/p300 binding in human tracheal smooth muscle cells
TNF-α has been shown to induce matrix metalloproteinase-9 (MMP-9) expression, which, in turn, degrades extracellular matrix in… 
Highly Cited
2007
Highly Cited
2007
Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity.
Highly Cited
2004
Highly Cited
2004
Sphingosine 1-Phosphate Transactivates the Platelet-Derived Growth Factor β Receptor and Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells
Abstract— Sphingosine 1-phosphate (S1P) is a bioactive lipid generated during vascular injury that regulates cell growth… 
Highly Cited
2003
Highly Cited
2003
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.
Activating mutations of FLT3 have been detected in patients with acute myeloid leukemia (AML). Two distinct types of FLT3… 
Highly Cited
2002
Highly Cited
2002
Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
FLT3 is a receptor tyrosine kinase that may play a role in a significant proportion of leukemias. In addition to being aberrantly… 
Highly Cited
2001
Highly Cited
2001
JAK/STAT Signaling Is Associated With Cardiac Dysfunction During Ischemia and Reperfusion
Background—Activation of the heart renin-angiotensin system (RAS) under pathophysiological conditions has been correlated with… 
Highly Cited
2000
Highly Cited
2000
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
In the present study, we examined the underlying mechanism, which causes the constitutive tyrosine phosphorylation of signal… 
Highly Cited
1998
Highly Cited
1998
Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways
1 In human epithelial‐like DLD‐1 cells, nitric oxide synthase (NOS) II expression was induced by interferon‐γ (100 u ml−1) alone… 
Highly Cited
1998
Highly Cited
1998
PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.
BACKGROUND Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to… 
Highly Cited
1996
Highly Cited
1996
Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes.
To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and… 
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