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AG-1296

Known as: AG1296, tyrphostin-AG1296, AG 1296 
A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

6,7-dimethoxy-3-phenylquinoxalineNitrilesQuinoxalines
Receptor Tyrosine Kinase Inhibition

Papers overview

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2010
2010
Reply: Blockade of Janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.
Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is one of the major pathways for cytokine… 
2008
2008
Epidermal growth factor stimulates Rac1 and p21-activated kinase in vascular smooth muscle cells.
2007
2007
Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the α-Platelet–Derived Growth Factor Receptor
The factors regulating the bone tropism of disseminated prostate cancer cells are still vaguely defined. We report that prostate… 
Highly Cited
2003
Highly Cited
2003
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.
An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with… 
2001
2001
Effects of (-)-epigallocatechin-3-gallate, the main component of green tea, on the cloned rat brain Kv1.5 potassium channels.
2000
2000
Involvement of Protein Tyrosine Kinase in Osmoregulation of Na+ Transport and Membrane Capacitance in Renal A6 Cells
Abstract. Renal A6 cells have been reported in which hyposmolality stimulates Na+ transport by increasing the number of… 
Highly Cited
1999
Highly Cited
1999
Activation of Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and apigenin.
The present study investigates regulation of Cl- channels and Na+/K+/2Cl- cotransporter in a renal epithelial cell line, A6, by… 
1999
1999
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the… 
1998
1998
Suppression of Experimental Autoimmune Encephalomyelitis by Tyrphostin AG-556
Tyrosine kinase blockers from the AG 126/AG-556 tyrphostin family are shown to inhibit the lipopolysaccharide (LPS)-induced… 
1997
1997
Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.
Coexpression of the Kit receptor tyrosine kinase and its ligand, stem cell factor (SCF), occurs in a high proportion of small… 
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