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Objective—Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular… Expand Activation of the erythropoietin receptor (EpoR) after Epo binding is very transient because of the rapid activation of strong… Expand Recent evidence suggests that Rho/Rho kinase signaling plays an important role in the sustained vasoconstriction induced by many… Expand BACKGROUND
The prognosis of primary renal disease is often dependent on the degree of tubulointerstitial scarring. Scarring is… Expand The chemokines are a growing family of low m.w., 70- to 80-residue proinflammatory cytokines that operate by interacting with G… Expand BACKGROUND
The gene Sry acts as a developmental switch, initiating a pathway of gene activity that leads to the differentiation… Expand Alteration in the expression and activation of protein tyrosine kinases and cell cycle regulatory genes not only can lead… Expand The mechanism of action of AG1296, a potent and specific inhibitor of the platelet-derived growth factor (PDGF) receptor tyrosine… Expand To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and… Expand A novel class of tyrosine kinase blockers represented by the tyrphostins AG1295 and AG1296 is described. These compounds inhibit… Expand