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AG-1296

Known as: AG1296, tyrphostin-AG1296, AG 1296 
A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Objective—Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular… Expand
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Highly Cited
2007
Highly Cited
2007
TNF-α has been shown to induce matrix metalloproteinase-9 (MMP-9) expression, which, in turn, degrades extracellular matrix in… Expand
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Highly Cited
2005
Highly Cited
2005
Activation of the erythropoietin receptor (EpoR) after Epo binding is very transient because of the rapid activation of strong… Expand
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Highly Cited
2004
Highly Cited
2004
Recent evidence suggests that Rho/Rho kinase signaling plays an important role in the sustained vasoconstriction induced by many… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The prognosis of primary renal disease is often dependent on the degree of tubulointerstitial scarring. Scarring is… Expand
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Highly Cited
1998
Highly Cited
1998
The chemokines are a growing family of low m.w., 70- to 80-residue proinflammatory cytokines that operate by interacting with G… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The gene Sry acts as a developmental switch, initiating a pathway of gene activity that leads to the differentiation… Expand
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Highly Cited
1997
Highly Cited
1997
The mechanism of action of AG1296, a potent and specific inhibitor of the platelet-derived growth factor (PDGF) receptor tyrosine… Expand
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Highly Cited
1996
Highly Cited
1996
To understand the signalling mechanisms involved in the dual stimulatory effects of endothelin-1 (ET-1) on DNA synthesis and… Expand
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Highly Cited
1994
Highly Cited
1994
A novel class of tyrosine kinase blockers represented by the tyrphostins AG1295 and AG1296 is described. These compounds inhibit… Expand
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