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AG-1296

Known as: AG1296, tyrphostin-AG1296, AG 1296 
A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

6,7-dimethoxy-3-phenylquinoxalineNitrilesQuinoxalines
Receptor Tyrosine Kinase Inhibition

Papers overview

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Highly Cited
2007
Highly Cited
2007
TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells.
TNF-alpha has been shown to induce matrix metalloproteinase-9 (MMP-9) expression, which, in turn, degrades extracellular matrix… 
Highly Cited
2007
Highly Cited
2007
Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells
Purpose The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism… 
Highly Cited
2006
Highly Cited
2006
Airway hyper‐responsiveness in allergic asthma in guinea‐pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that… 
Highly Cited
2003
Highly Cited
2003
Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.
An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with… 
2001
2001
Epidermal growth factor activates store-operated calcium channels in human glomerular mesangial cells.
Acellular influx of Ca2+ is critical for initiating and maintaining growth in a variety of cell types. Experiments were performed… 
2001
2001
LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42.
The Janus kinase (JAK) family of protein tyrosine kinases are activated in response to a wide variety of external stimuli. Here… 
2001
2001
Mechanisms of leukotriene D4‐induced constriction in human small bronchioles
We examined the mechanisms underlying leukotriene D4‐ (LTD4) induced constriction of human small (300 – 500 μm i.d.) bronchioles… 
Highly Cited
2001
Highly Cited
2001
Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes
Growth hormone (GH) has been reported to be useful to treat heart failure. To elucidate whether GH has direct beneficial effects… 
1999
1999
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the… 
Highly Cited
1999
Highly Cited
1999
Activation of Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and apigenin.
The present study investigates regulation of Cl- channels and Na+/K+/2Cl- cotransporter in a renal epithelial cell line, A6, by… 
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