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AFN 1252

Known as: AFN-1252, AFN1252 
 
National Institutes of Health

Papers overview

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2015
2015
ABSTRACT This open-label noncontrolled, phase II multicenter trial was designed to evaluate the safety, tolerability, and… Expand
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2015
2015
AIMS AFN-1252 is a novel inhibitor of FabI, an essential enzyme in Staphylococcus spp. This study was undertaken to assess the… Expand
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2013
2013
OBJECTIVES To investigate the absorption, distribution, metabolism and excretion of AFN-1252, a novel inhibitor of the essential… Expand
2013
2013
Abstract AFN-1252 is a novel inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252… Expand
2013
2013
Abstract AFN-1252, a new antimicrobial agent, specifically and potently inhibits fatty acid synthesis in Staphylococcus aureus… Expand
2013
2013
Background: AFN-1252 is a FabI inhibitor developed to treat Staphylococcus aureus. Results: AFN-1252 resistance arises from a… Expand
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2013
2013
ABSTRACT This study examines the alteration in Staphylococcus aureus gene expression following treatment with the type 2 fatty… Expand
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Highly Cited
2012
Highly Cited
2012
ABSTRACT The mechanism of action of AFN-1252, a selective inhibitor of Staphylococcus aureus enoyl-acyl carrier protein reductase… Expand
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Highly Cited
2009
Highly Cited
2009
ABSTRACT AFN-1252, a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of… Expand
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1999
1999
Fibronectin (Fn) is a major adhesive protein found in the hepatic extracellular matrix (ECM). In adult rats, the in vivo turnover… Expand