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AF-9 protein

Known as: Myeloid/Lymphoid or Mixed-Lineage Leukemia Translocated to Chromosome 3 Protein, Trithorax Homolog 3, YEATS Domain-Containing Protein 3 
Protein AF-9 (568 aa, ~63 kDa) is encoded by the human MLLT3 gene. This protein may play a role in the regulation of transcription.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Recognition of histone covalent modifications by chromatin-binding protein modules ("readers") constitutes a major mechanism for… Expand
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Highly Cited
2015
Highly Cited
2015
The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently… Expand
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Highly Cited
2014
Highly Cited
2014
The recognition of modified histones by "reader" proteins constitutes a key mechanism regulating gene expression in the chromatin… Expand
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Highly Cited
2014
Highly Cited
2014
SIRT1 is an important regulator of cellular stress response and genomic integrity. Its role in tumorigenesis is controversial… Expand
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2013
2013
Mixed lineage leukemia (MLL) fusion proteins cause oncogenic transformation of hematopoietic cells by constitutive recruitment of… Expand
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Highly Cited
2011
Highly Cited
2011
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion… Expand
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Highly Cited
2010
Highly Cited
2010
Recruitment of the P-TEFb kinase by HIV-1 Tat to the viral promoter triggers the phosphorylation and escape of RNA polymerase II… Expand
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Highly Cited
2008
Highly Cited
2008
Human leukemias harboring chromosomal translocations involving the mixed lineage leukemia (MLL, HRX, ALL-1) gene possess high… Expand
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Highly Cited
2007
Highly Cited
2007
AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia, encodes a putative… Expand
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2003
2003
Natural variations of wild Caenorhabditis elegans isolates having either Phe-215 or Val-215 in NPR-1, a putative orphan… Expand
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