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AF-9 protein

Known as: Myeloid/Lymphoid or Mixed-Lineage Leukemia Translocated to Chromosome 3 Protein, Trithorax Homolog 3, YEATS Domain-Containing Protein 3 
Protein AF-9 (568 aa, ~63 kDa) is encoded by the human MLLT3 gene. This protein may play a role in the regulation of transcription.
National Institutes of Health

Related topics

Related topics

7 relations
DNA-Binding ProteinsGenes, RegulatorMLLT3 geneMLLT3 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Solution NMR structure of BCoR in complex with AF9 (BCoR-AF9)
Review
2014
Review
2014
MYELOID NEOPLASIA shRNA screening identi fi es JMJD 1 C as being required for leukemia maintenance
Translocations involvingmixed lineage leukemia (MLL) gene occur frequently in acute leukemia, especially in childhood and… 
2014
2014
An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.
Misregulation of transcription elongation is proposed to underlie the pathobiology of MLL leukemia. AF4, AF9, and ENL, common MLL… 
2013
2013
Structural and Functional Studies Of The Intrinsically Disordered Protein AF9 In MLL-AF9 Leukemia
Mixed lineage leukemias are characterized by the creation of a chimeric fusion protein where MLL is fused in frame to over 60… 
2012
2012
Etoposide-induced apoptosis results in chromosome breaks within the AF9 gene: Its implication in chromosome rearrangement in leukaemia
Treatment with etoposide (VP-16) has been associated with translocation of the mixed lineage leukaemia (MLL) gene seen in… 
2011
2011
Ezh2 Plays a Critical Role in the Progression of MLL-AF9 -Induced Acute Myeloid Leukemia
Abstract 57 The polycomb group proteins function in gene silencing through histone modifications. They have been characterized as… 
2010
2010
af9 Regulates gata2 Expression During Early Hemangioblast Specification and Vascular Pattern Formation In Zebrafish.
Abstract 2600 Background AF9 is a transcription factor that plays an essential role in hematopoiesis and embryonic development… 
2006
2006
The Mll-AF9 Knock-In Fusion Gene Results in Reprogramming and Enhanced Self-Renewal of Hematopoietic Progenitors, Especially in the HSC and CLP Populations.
The relative importance of the major hematopoietic progenitor/stem cell populations in MLL fusion gene leukemias remains largely… 
1978
1978
5a-AF-9 点熱源による熱対流 : 計算
1978
1978
3p-AF-9 広田回路によるソリトンの実験II
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