MLLT3 gene

Known as: Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 3 Gene, MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 3, MLLT3 
This gene plays a role in transcriptional regulation and translocations in the gene are associated with leukemia.

Topic mentions per year

Topic mentions per year

1993-2017
05101519932017

Papers overview

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Highly Cited
2012
Highly Cited
2012
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific demethylase KDM1A (LSD1 or AOF2) as an essential… (More)
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Highly Cited
2011
Highly Cited
2011
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion… (More)
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Highly Cited
2010
Highly Cited
2010
Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process… (More)
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Highly Cited
2008
Highly Cited
2008
Human leukemias harboring chromosomal translocations involving the mixed lineage leukemia (MLL, HRX, ALL-1) gene possess high… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in understanding the biology of MLL fusion… (More)
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2004
2004
The MLL gene is involved in translocations associated with both acute lymphoblastic and acute myelogenous leukemia. These… (More)
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2001
2001
Polycomb group (PcG) proteins assemble to form large multiprotein complexes involved in gene silencing. Evidence suggests that… (More)
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Highly Cited
1999
Highly Cited
1999
The MLL gene from human chromosome 11q23 is involved in >30 different chromosomal translocations resulting in a plethora of… (More)
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1996
1996
The SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products are all required for proper transcriptional control of many genes in… (More)
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Highly Cited
1993
Highly Cited
1993
Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1… (More)
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