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MLLT3 gene

Known as: Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 3 Gene, MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 3, MLLT3 
This gene plays a role in transcriptional regulation and translocations in the gene are associated with leukemia.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic… Expand
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Highly Cited
2014
Highly Cited
2014
Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells. Since the regenerative capacity of normal… Expand
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Highly Cited
2011
Highly Cited
2011
The Super Elongation Complex (SEC), containing transcription elongation activators/coactivators P-TEFb, ELL2, AFF4/1, ENL, and… Expand
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Highly Cited
2010
Highly Cited
2010
Chimeric oncoproteins resulting from fusion of MLL to a wide variety of partnering proteins cause biologically distinctive and… Expand
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Highly Cited
2008
Highly Cited
2008
The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely… Expand
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Highly Cited
2007
Highly Cited
2007
AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia, encodes a putative… Expand
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Highly Cited
2007
Highly Cited
2007
Aldosterone plays a major role in the regulation of salt balance and the pathophysiology of cardiovascular and renal diseases… Expand
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Highly Cited
2006
Highly Cited
2006
Leukaemias and other cancers possess a rare population of cells capable of the limitless self-renewal necessary for cancer… Expand
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Review
2006
Review
2006
Recurring chromosome abnormalities are strongly associated with certain subtypes of leukemia, lymphoma and sarcomas. More… Expand
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Highly Cited
2006
Highly Cited
2006
Aldosterone is a major regulator of epithelial Na+ absorption and acts in large part through induction of the epithelial Na… Expand
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