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MLLT3 gene

Known as: Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 3 Gene, MIXED LINEAGE LEUKEMIA, TRANSLOCATED TO, 3, MLLT3 
This gene plays a role in transcriptional regulation and translocations in the gene are associated with leukemia.
National Institutes of Health

Related topics

Related topics

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AF-9 proteinHomo sapiensMLLT3 wt AlleleTranscriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Ets1 Plays a Critical Role in MLL/EB1-Mediated Leukemic Transformation in a Mouse Bone Marrow Transplantation Model
2017
2017
Effect of aldosterone on cochlear Af9 expression and hearing in guinea pig
Abstract Conclusions: Af9 protein in cochlea may be closely related to endolymph regulation by aldosterone and thus may be… 
2016
2016
The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression
BackgroundIn this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL… 
2015
2015
NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions
Acute myeloid leukemia (AML) is an aggressive hematological malignancy, and the mechanism underlying immune system involvement in… 
2014
2014
An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias.
Misregulation of transcription elongation is proposed to underlie the pathobiology of MLL leukemia. AF4, AF9, and ENL, common MLL… 
2006
2006
Validation of an interphase fluorescence in situ hybridization approach for the detection of MLL gene rearrangements and of the MLL/AF9 fusion in acute myeloid leukemia.
To validate a 2-step FISH assay for the identification of the t(9;11)(p22;q23), 96 acute myeloid leukemias were studied by… 
2004
2004
Cryptic insertion of MLL gene into 9p22 leads to MLL–MLLT3 (AF9) fusion in a case of acute myelogenous leukemia
The formation of a leukemogenic fusion product in hematopoietic malignancies is commonly achieved by chromosomal translocation… 
Highly Cited
2000
Highly Cited
2000
The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation.
Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a role in regulating… 
1997
1997
Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.
The MLL gene at chromosome 11, band q23, is involved in translocations with as many as 40 different chromosomal bands. Virtually… 
Highly Cited
1980
Highly Cited
1980
Divalent antibodies to mouse embryonal carcinoma cells inhibit compaction in the mouse embryo.
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