AF-219
National Institutes of Health
Papers overview
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ABSTRACT Introduction: Purinergic P2X3-P2X2/3 receptors are placed in nociceptive neurons’ strategic location and show unique…
Significance Allosteric regulation, produced by the binding of a ligand at an allosteric site topographically distinct from the…
Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and…
Introduction: MK-7264 (formerly AF-219) is a P2X3 receptor antagonist that has been shown to reduce cough frequency in patients…
Introduction and objectives Effective therapies for chronic cough are a significant unmet need. Recently a P2X3 antagonist (AF…
Abstract:Treatments for inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), functional dyspepsia, or motility…
P2X3 receptors are ATP‐gated channels with expression somewhat limited to primary afferent populations suspected of chronic…
Background
Pre-clinical studies suggest that P2X3 receptors are expressed by airway vagal afferents and contribute to the…
The P2X3 antagonist AF‐219, being studied in bladder disorders, is eliminated by renal clearance. Local renal delivery of AF‐219…