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AF-219

 
National Institutes of Health

Papers overview

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2018
2018
  • J. Wang, Yao Wang, +11 authors Y. Yu
  • Proceedings of the National Academy of Sciences
  • 2018
  • Corpus ID: 4981140
Significance Allosteric regulation, produced by the binding of a ligand at an allosteric site topographically distinct from the… Expand
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Review
2017
Review
2017
Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and… Expand
2017
2017
Introduction: MK-7264 (formerly AF-219) is a P2X3 receptor antagonist that has been shown to reduce cough frequency in patients… Expand
2016
2016
Introduction and objectives Effective therapies for chronic cough are a significant unmet need. Recently a P2X3 antagonist (AF… Expand
2016
2016
Introduction: Chronic cough is a challenging problem as available medications lack proven efficacy. AF-219, a P2X3 antagonist… Expand
Highly Cited
2015
Highly Cited
2015
BACKGROUND Preclinical studies suggest that P2X3 receptors are expressed by airway vagal afferent nerves and contribute to the… Expand
2015
2015
Hypothesis / aims of study P2X3 purinoceptors drive sensitization of bladder sensory neurons in response to ATP, causing chronic… Expand
2015
2015
www.thelancet.com Vol 386 July 18, 2015 245 As stated, both patients with a smoking history of more than 20 pack-years and those… Expand
2013
2013
Background Pre-clinical studies suggest that P2X3 receptors are expressed by airway vagal afferents and contribute to the… Expand