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AF-219

 
National Institutes of Health

Papers overview

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2018
2018
Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion channels, and G protein-coupled… Expand
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Review
2017
Review
2017
Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and… Expand
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2016
2016
Introduction and objectives Effective therapies for chronic cough are a significant unmet need. Recently a P2X3 antagonist (AF… Expand
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2016
2016
Introduction: Chronic cough is a challenging problem as available medications lack proven efficacy. AF-219, a P2X3 antagonist… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Preclinical studies suggest that P2X3 receptors are expressed by airway vagal afferent nerves and contribute to the… Expand
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2015
2015
www.thelancet.com Vol 386 July 18, 2015 245 As stated, both patients with a smoking history of more than 20 pack-years and those… Expand
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2015
2015
Hypothesis / aims of study P2X3 purinoceptors drive sensitization of bladder sensory neurons in response to ATP, causing chronic… Expand
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2015
2015
References 1 Morice AH, Millqvist E, Belvisi MG, et al. Expert opinion on the cough hypersensitivity syndrome in respiratory… Expand
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2013
2013
Background Pre-clinical studies suggest that P2X3 receptors are expressed by airway vagal afferents and contribute to the… Expand
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