AF-219
National Institutes of Health
Papers overview
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Introduction: MK-7264 (formerly AF-219) is a P2X3 receptor antagonist that has been shown to reduce cough frequency in patients…
Introduction and objectives Effective therapies for chronic cough are a significant unmet need. Recently a P2X3 antagonist (AF…
Objective: Arterial hypertension is associated with increases in both peripheral chemoreceptor reflex sensitivity and sympathetic…
trolled by existing therapies owing, in part, to resistance to antihypertensive medications, poor compliance and side effects…
OBJECTIVE
Arterial hypertension is associated with increases in both peripheral chemoreceptor reflex sensitivity and sympathetic…
Patienten und Methoden: Die doppelblinde, placebokontrollierte Crossover-Studie wurde in einem britischen Zentrum durchgeführt…
Introduction: Patients with chronic cough suffer
significantly from impaired quality of life. However, safe and
well-tolerated…
The P2X3 antagonist AF‐219, being studied in bladder disorders, is eliminated by renal clearance. Local renal delivery of AF‐219…