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ADW 742

Known as: ADW-742, ADW742 
National Institutes of Health

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2 relations

Broader (2)

PyrimidinesPyrroles

Papers overview

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2020
2020
Targeting Insulin-Like Growth Factor 1 Receptor Delays M-Phase Progression and Synergizes with Aurora B Inhibition to Suppress Cell Proliferation
The insulin-like growth factor 1 receptor (IGF1R) is a receptor-type tyrosine kinase that transduces signals related to cell… 
2011
2011
The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy.
Medulloblastoma is the most common malignant tumor of the central nervous system in children. The insulin-like growth factor-I… 
Highly Cited
2006
Highly Cited
2006
Insulin-Like Growth Factor I Receptor Pathway Inhibition by ADW742, Alone or in Combination with Imatinib, Doxorubicin, or Vincristine, Is a Novel Therapeutic Approach in Ewing Tumor
Purpose: Ewing tumor cell survival and proliferation depends on several autocrine loops. Targeting these loops is a promising… 
2005
2005
Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Highly Cited
2004
Highly Cited
2004
The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor…
Stem cell factor (SCF)/Kit and insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) autocrine loops play a prominent role… 
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